PMID- 24747058
OWN - NLM
STAT- MEDLINE
DCOM- 20141027
LR  - 20220330
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 13
IP  - 8
DP  - 2014 Aug
TI  - Autoimmune diseases in HIV-infected patients: 52 cases and literature review.
PG  - 850-7
LID - S1568-9972(14)00118-9 [pii]
LID - 10.1016/j.autrev.2014.04.005 [doi]
AB  - OBJECTIVES: 1) To describe autoimmune diseases (AD) in HIV-infected people; and 
      2) to perform a literature review concerning this issue. DESIGN: 52 HIV-infected 
      patients that presented an AD in 14 medical departments in Paris and 
      Ile-de-France area were retrospectively included in this study. RESULTS: The ADs 
      were vasculitis (11), immune cytopenias (8), rheumatic diseases (8), lupus (7), 
      sarcoidosis (7), thyroid diseases (6), hepatic diseases (5), and antiphospholipid 
      syndrome (4). Four patients presented 2 ADs. In 5 patients the AD preceded HIV 
      infection, in 14 HIV infection was diagnosed at the same time as the AD and 34 
      were HIV-infected when they developed an AD. 40 ADs (80%) occurred in patients 
      with a CD4 T lymphocyte count of more than 200/mm(3). Cases of autoimmune 
      hemolytic anemia occurred only in patients severely immunodepressed. In five 
      patients (a vasculitis case, a sarcoidosis case, three thyroid disease cases) the 
      AD presented as a form of immune restoration inflammatory syndrome (IRIS). Some 
      ADs allowed HIV-infection diagnosis at a stage of moderate immune deficiency 
      (vasculitis, antiphospholipid syndrome, immune thrombocytopenia). 37 patients 
      received immunosuppressant treatments with good tolerance. These results confirm 
      in a large series of patients previous data concerning autoimmune diseases 
      occurrence in HIV-infected people. CONCLUSION: In the HAART era, when 
      HIV-infected people are treated more and more early, autoimmune diseases can 
      occur, mainly at the phase of immunological recovery. HIV infection should not 
      limit immunosuppressant treatment use.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Iordache, Laura
AU  - Iordache L
AD  - Internal Medicine Department, Jean Verdier Hospital, Avenue du 14 Juillet, 93140 
      Bondy, France. Electronic address: laura.iordache@sls.aphp.fr.
FAU - Launay, Odile
AU  - Launay O
AD  - Clinical Investigation Centre, Cochin Hospital, 27 rue du Fbg St.-Jacques, 75014 
      Paris, France.
FAU - Bouchaud, Olivier
AU  - Bouchaud O
AD  - Infectious Diseases Department, Avicenne Hospital, 125 rue de Stalingrad, 93009 
      Bobigny, France.
FAU - Jeantils, Vincent
AU  - Jeantils V
AD  - Infectious Diseases Department, Jean Verdier Hospital, Avenue du 14 Juillet, 
      93140 Bondy, France.
FAU - Goujard, Cecile
AU  - Goujard C
AD  - Internal Medicine Department, Kremlin Bicetre Hospital, 78 rue du General 
      Leclerc, 94270 Le Kremlin-Bicetre, France.
FAU - Boue, Francois
AU  - Boue F
AD  - Internal Medicine Department, Antoine Beclere Hospital, 157 rue de la Porte de 
      Trivaux, 92140 Clamart, France.
FAU - Cacoub, Patrice
AU  - Cacoub P
AD  - Internal Medicine and Clinical Immunology Department, Pitie-Salpetriere Hospital, 
      47-83 bd de l'Hopital, 75013 Paris, France; Hospital-University Department I2B, 
      Sorbonne Universites, UPMC Paris 6 University, UMR 7211, F-75005, Paris, France; 
      INSERM, UMR S959, F-75013, Paris, France; CNRS, UMR 7211, F-75005, Paris, France.
FAU - Hanslik, Thomas
AU  - Hanslik T
AD  - Internal Medicine Department, Ambroise Pare Hospital, 9 Avenue Charles-de-Gaulle, 
      92100 Boulogne Billancourt, France.
FAU - Mahr, Alfred
AU  - Mahr A
AD  - Internal Medicine Department, St. Louis Hospital, 1 Avenue Claude-Vellefaux, 
      75010 Paris, France.
FAU - Lambotte, Olivier
AU  - Lambotte O
AD  - Internal Medicine Department, Kremlin Bicetre Hospital, 78 rue du General 
      Leclerc, 94270 Le Kremlin-Bicetre, France.
FAU - Fain, Olivier
AU  - Fain O
AD  - Internal Medicine Department, Jean Verdier Hospital, Avenue du 14 Juillet, 93140 
      Bondy, France.
CN  - Associated authors
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140418
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - Autoimmune Diseases/*complications/drug therapy/epidemiology/immunology
MH  - Follow-Up Studies
MH  - France
MH  - HIV Infections/*complications/drug therapy/epidemiology/immunology
MH  - Humans
MH  - Immune Tolerance
OTO - NOTNLM
OT  - Autoimmunity
OT  - HIV
OT  - Immunosuppressant drugs
FIR - Delassus, Jean-Luc
IR  - Delassus JL
FIR - Dhote, Robin
IR  - Dhote R
FIR - Fior, Renato
IR  - Fior R
FIR - Galicier, Lionel
IR  - Galicier L
FIR - Guillevin, Loic
IR  - Guillevin L
FIR - Honore, Patricia
IR  - Honore P
FIR - Manea, Maria
IR  - Manea M
FIR - Mekinian, Arsene
IR  - Mekinian A
FIR - de Menthon, Mathilde
IR  - de Menthon M
FIR - Nunes, Hilario
IR  - Nunes H
FIR - Pillebout, Evangeline
IR  - Pillebout E
FIR - Raho, Mariem
IR  - Raho M
FIR - Weiss, Laurence
IR  - Weiss L
EDAT- 2014/04/22 06:00
MHDA- 2014/10/28 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/03/27 00:00 [received]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/10/28 06:00 [medline]
AID - S1568-9972(14)00118-9 [pii]
AID - 10.1016/j.autrev.2014.04.005 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2014 Aug;13(8):850-7. doi: 10.1016/j.autrev.2014.04.005. Epub 2014 
      Apr 18.