PMID- 24747095
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140602
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 21
IP  - 1
DP  - 2014 Jul
TI  - Effects of high-dose intravenous immunoglobulin on lipopolysaccharide-induced 
      acute lung injury.
PG  - 51-5
LID - S1567-5769(14)00123-4 [pii]
LID - 10.1016/j.intimp.2014.04.002 [doi]
AB  - PURPOSE: Intravenous immunoglobulin (IVIG) therapy is used in inflammatory 
      diseases but the use of immunoglobulin as a treatment for acute lung injury (ALI) 
      has not been previously studied. Transforming growth factor beta (TGF-beta) plays a 
      critical role in the pathogenesis of of ALI. Therefore we examined the levels of 
      TGF-beta and lung inflammation scores in IVIG treated ALI models. METHODS: 
      Intratracheal lipopolysacccharide was given to rats. Groups 1 and 3 received 
      saline, whereas group 2 received IVIG. 24h later saline was given to groups 1 and 
      2 and IVIG to group 3. Blood samples and bronchoalveolar lavage (BAL) fluids were 
      obtained from each group and sacrificed for pathological evaluation. RESULTS: BAL 
      TGF-beta levels of groups 2 and 3 on day 30, were lower compared to their levels of 
      day 2 (p=0.01, p=0.01). BAL TGF-beta levels of groups 2 and 3 were lower than the 
      levels of group 1 on day 30 (p=0.002, p=0.001). Pathological examination revealed 
      that the inflammation scores of groups 2 and 3 on day 30, were lower than the 
      scores of day 2 (p=0.02, p=0.01). Inflammation scores of group 2 were lower than 
      group 1 on day 30 (p=0.02). Moderate fibrosis was seen in half of the rats from 
      group 1 and one rat from group 2. CONCLUSION: High-dose IVIG decreased lung 
      inflammation scores and BAL TGF-beta1 levels and this therapy would give even better 
      results if it is given earlier.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Oygucu, Seyhan Erisir
AU  - Oygucu SE
AD  - Division of Neonatology, Department of Pediatrics, School of Medicine, Akdeniz 
      University, Antalya, Turkey. Electronic address: seoygucu@hotmail.com.
FAU - Ozbudak, Irem Hicran
AU  - Ozbudak IH
AD  - Department of Pathology, School of Medicine, Akdeniz University, Antalya, Turkey. 
      Electronic address: iremhicrang@hotmail.com.
FAU - Akcan, Abdullah Baris
AU  - Akcan AB
AD  - Division of Neonatology, Department of Pediatrics, School of Medicine, Akdeniz 
      University, Antalya, Turkey. Electronic address: barisakc@hotmail.com.
FAU - Coskun, Mesut
AU  - Coskun M
AD  - Department of Immunology, School of Medicine, Akdeniz University, Antalya, 
      Turkey. Electronic address: mesutcoskun@akdeniz.edu.tr.
FAU - Ozel, Deniz
AU  - Ozel D
AD  - Department of Biostatistics and Medical Informatics, School of Medicine, Akdeniz 
      University, Antalya, Turkey. Electronic address: denizeozel@gmail.com.
FAU - Ozbilim, Gulay
AU  - Ozbilim G
AD  - Department of Pathology, School of Medicine, Akdeniz University, Antalya, Turkey. 
      Electronic address: gulayozbilim@akdeniz.edu.tr.
FAU - Oygur, Nihal
AU  - Oygur N
AD  - Division of Neonatology, Department of Pediatrics, School of Medicine, Akdeniz 
      University, Antalya, Turkey. Electronic address: nihaloygur@akdeniz.edu.tr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140418
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Acute Lung Injury/chemically induced/*drug therapy
MH  - Animals
MH  - Fibrosis/chemically induced/*drug therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage/adverse effects
MH  - Lipopolysaccharides/immunology
MH  - Lung/*drug effects/immunology
MH  - Male
MH  - Pneumonia/*drug therapy
MH  - Rats
MH  - Rats, Wistar
MH  - Transforming Growth Factor beta/metabolism
OTO - NOTNLM
OT  - Acute lung injury
OT  - Transforming growth factor beta (TGF-beta)
OT  - Immunoglobulin
OT  - Inflammation
EDAT- 2014/04/22 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/04/22 06:00
PHST- 2014/01/16 00:00 [received]
PHST- 2014/03/20 00:00 [revised]
PHST- 2014/04/01 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S1567-5769(14)00123-4 [pii]
AID - 10.1016/j.intimp.2014.04.002 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2014 Jul;21(1):51-5. doi: 10.1016/j.intimp.2014.04.002. Epub 
      2014 Apr 18.