PMID- 24747593
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20220311
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Apr 17
TI  - Vitamin D: link between osteoporosis, obesity, and diabetes?
PG  - 6569-91
LID - 10.3390/ijms15046569 [doi]
AB  - Vitamin D (1,25(OH)2D3) is a steroid hormone that has a range of physiological 
      functions in skeletal and nonskeletal tissues, and can contribute to prevent 
      and/or treat osteoporosis, obesity, and Type 2 diabetes mellitus (T2DM). In bone 
      metabolism, vitamin D increases the plasma levels of calcium and phosphorus, 
      regulates osteoblast and osteoclast the activity, and combats PTH hypersecretion, 
      promoting bone formation and preventing/treating osteoporosis. This evidence is 
      supported by most clinical studies, especially those that have included calcium 
      and assessed the effects of vitamin D doses (>/=800 IU/day) on bone mineral 
      density. However, annual megadoses should be avoided as they impair bone health. 
      Recent findings suggest that low serum vitamin D is the consequence (not the 
      cause) of obesity and the results from randomized double-blind clinical trials 
      are still scarce and inconclusive to establish the relationship between vitamin 
      D, obesity, and T2DM. Nevertheless, there is evidence that vitamin D inhibits fat 
      accumulation, increases insulin synthesis and preserves pancreatic islet cells, 
      decreases insulin resistance and reduces hunger, favoring obesity and T2DM 
      control. To date, there is not enough scientific evidence to support the use of 
      vitamin D as a pathway to prevent and/or treat obesity and T2DM.
FAU - Candido, Flavia Galvao
AU  - Candido FG
AD  - Laboratory of Body Composition and Energy Metabolism, Departamento de Nutricao e 
      Saude-CCB II, Universidade Federal de Vicosa, Avenida PH Rolfs, s/n, Vicosa, MG 
      36570-900, Brazil. flaviagcandido@hotmail.com.
FAU - Bressan, Josefina
AU  - Bressan J
AD  - Laboratory of Body Composition and Energy Metabolism, Departamento de Nutricao e 
      Saude-CCB II, Universidade Federal de Vicosa, Avenida PH Rolfs, s/n, Vicosa, MG 
      36570-900, Brazil. ppgcnut@ufv.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140417
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Bone Density
MH  - Diabetes Mellitus, Type 2/metabolism/pathology
MH  - Humans
MH  - Obesity/metabolism/pathology
MH  - Osteoporosis/metabolism/pathology
MH  - Vitamin D/chemistry/*metabolism
PMC - PMC4013648
EDAT- 2014/04/22 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/04/01
CRDT- 2014/04/22 06:00
PHST- 2014/02/24 00:00 [received]
PHST- 2014/03/24 00:00 [revised]
PHST- 2014/04/04 00:00 [accepted]
PHST- 2014/04/22 06:00 [entrez]
PHST- 2014/04/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - ijms15046569 [pii]
AID - ijms-15-06569 [pii]
AID - 10.3390/ijms15046569 [doi]
PST - epublish
SO  - Int J Mol Sci. 2014 Apr 17;15(4):6569-91. doi: 10.3390/ijms15046569.