PMID- 24751794
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20220318
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 4
DP  - 2014
TI  - Soluble ST2 and interleukin-33 levels in coronary artery disease: relation to 
      disease activity and adverse outcome.
PG  - e95055
LID - 10.1371/journal.pone.0095055 [doi]
LID - e95055
AB  - OBJECTIVES: ST2 is a receptor for interleukin (IL)-33. We investigated an 
      association of soluble ST2 (sST2) and IL-33 serum levels with different clinical 
      stages of coronary artery disease. We assessed the predictive value of sST2 and 
      IL-33 in patients with stable angina, non-ST elevation myocardial infarction 
      (NSTEMI) and ST elevation myocardial infarction (STEMI). METHODS: We included 373 
      patients of whom 178 had stable angina, 97 had NSTEMI, and 98 had STEMI. Patients 
      were followed for a mean of 43 months. The control group consisted of 65 
      individuals without significant stenosis on coronary angiography. Serum levels of 
      sST2 and IL-33 were measured by ELISAs. RESULTS: sST2 levels were significantly 
      increased in patients with STEMI as compared to patients with NSTEMI and stable 
      angina as well as with controls. IL-33 levels did not differ between the four 
      groups. During follow-up, 37 (10%) patients died and the combined endpoint (all 
      cause death, MI and rehospitalisation for cardiac causes) occurred in 66 (17.6%) 
      patients. sST2 serum levels significantly predicted mortality in the total 
      cohort. When patients were stratified according to their clinical presentation, 
      the highest quintile of sST2 significantly predicted mortality in patients with 
      STEMI, but not with NSTEMI or stable coronary artery disease. sST2 was a 
      significant predictor for the combined endpoint in STEMI patients and in patients 
      with stable angina. Serum levels of IL-33 were not associated with clinical 
      outcome in the total cohort, but the highest quintile of IL-33 predicted 
      mortality in patients with STEMI. CONCLUSIONS: Serum levels of sST2 are increased 
      in patients with acute coronary syndromes as compared to levels in patients with 
      stable coronary artery disease and in individuals without coronary artery 
      disease. sST2 and IL-33 were associated with mortality in patients with STEMI but 
      not in patients with NSTEMI or stable angina.
FAU - Demyanets, Svitlana
AU  - Demyanets S
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, 
      Austria.
FAU - Speidl, Walter S
AU  - Speidl WS
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria.
FAU - Tentzeris, Ioannis
AU  - Tentzeris I
AD  - 3rd Medical Department for Cardiology and Emergency Medicine, 
      Wilhelminenhospital, Vienna, Austria.
FAU - Jarai, Rudolf
AU  - Jarai R
AD  - 3rd Medical Department for Cardiology and Emergency Medicine, 
      Wilhelminenhospital, Vienna, Austria.
FAU - Katsaros, Katharina M
AU  - Katsaros KM
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
FAU - Farhan, Serdar
AU  - Farhan S
AD  - 3rd Medical Department for Cardiology and Emergency Medicine, 
      Wilhelminenhospital, Vienna, Austria.
FAU - Krychtiuk, Konstantin A
AU  - Krychtiuk KA
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
FAU - Wonnerth, Anna
AU  - Wonnerth A
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
FAU - Weiss, Thomas W
AU  - Weiss TW
AD  - 3rd Medical Department for Cardiology and Emergency Medicine, 
      Wilhelminenhospital, Vienna, Austria.
FAU - Huber, Kurt
AU  - Huber K
AD  - 3rd Medical Department for Cardiology and Emergency Medicine, 
      Wilhelminenhospital, Vienna, Austria.
FAU - Wojta, Johann
AU  - Wojta J
AD  - Department of Internal Medicine II, Medical University of Vienna, Vienna, 
      Austria; Core Facilities, Medical University of Vienna, Vienna, Austria; Ludwig 
      Boltzmann Cluster for Cardiovascular Research, Vienna, Austria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140421
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (IL1RL1 protein, human)
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
RN  - 0 (Interleukin-33)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*blood/mortality
MH  - Female
MH  - Humans
MH  - Interleukin-1 Receptor-Like 1 Protein
MH  - Interleukin-33
MH  - Interleukins/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Receptors, Cell Surface/*blood
MH  - Risk Factors
MH  - Solubility
MH  - Treatment Outcome
PMC - PMC3994012
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/04/23 06:00
MHDA- 2015/01/21 06:00
PMCR- 2014/04/21
CRDT- 2014/04/23 06:00
PHST- 2013/09/10 00:00 [received]
PHST- 2014/03/23 00:00 [accepted]
PHST- 2014/04/23 06:00 [entrez]
PHST- 2014/04/23 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2014/04/21 00:00 [pmc-release]
AID - PONE-D-13-37242 [pii]
AID - 10.1371/journal.pone.0095055 [doi]
PST - epublish
SO  - PLoS One. 2014 Apr 21;9(4):e95055. doi: 10.1371/journal.pone.0095055. eCollection 
      2014.