PMID- 24753642
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140422
LR  - 20231104
IS  - 0253-0716 (Print)
IS  - 1735-3688 (Electronic)
IS  - 0253-0716 (Linking)
VI  - 39
IP  - 2 Suppl
DP  - 2014 Mar
TI  - Association between HLA-Class I and HLA-Class II Alleles and Mycobacterium 
      Tuberculosis Infection in Iraqi Patients from Baghdad City.
PG  - 191-5
AB  - BACKGROUND: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, 
      and among the suggested predisposing factors are alleles of the human leukocyte 
      antigen (HLA) system. We sought to investigate the association between HLA-class 
      I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients. 
      METHODS: lymphocytes of 105 PT patients and 40 controls were phenotyped for 
      HLA-A, -B, -DR, and -DQ alleles by means of the microlymphocytotoxicity test 
      using a panel of monoclonal antisera. RESULTS: HLA frequencies of B18 (16.2 vs. 
      2.5%; OD=7.53) and DR1 (51.4 vs. 10.0%; OD=9.53) alleles were significantly 
      increased in the patients as compared with the controls, while B5 (6.7 vs. 
      25.0%), DR8 (1.9 vs. 17.5%), and DQ3 (11.4 vs. 45.0%) alleles were significantly 
      decreased. However, a significant corrected level was maintained for only DR1, 
      DR8, and DQ3 alleles (Pc=1.9x10(-5), 0.02 and 1.0x10(-4), respectively). 
      CONCLUSION: The results confirm the predisposing and protecting roles of HLA 
      alleles in PT.
FAU - Mohammed, Nidhal Abdulmohaimen
AU  - Mohammed NA
AD  - Department of Microbiology, Al-Nahrain College of Medicine, Al-Nahrain 
      University, Baghdad, Iraq;
FAU - Qassem, Haitham
AU  - Qassem H
AD  - Microbiologist, College of Pharmacy, Al Mustansiyria University, Baghdad, Iraq;
FAU - Hassen, Farouk
AU  - Hassen F
AD  - Department of Microbiology, College of Medicine, Al Mustansiyria University, 
      Baghdad, Iraq.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Med Sci
JT  - Iranian journal of medical sciences
JID - 8104374
PMC - PMC3993047
OTO - NOTNLM
OT  - Lymphocytotoxicity
OT  - MHC-Class I
OT  - MHC-Class II
OT  - Tuberculosis
EDAT- 2014/04/23 06:00
MHDA- 2014/04/23 06:01
PMCR- 2014/03/01
CRDT- 2014/04/23 06:00
PHST- 2012/08/29 00:00 [received]
PHST- 2012/09/29 00:00 [revised]
PHST- 2012/10/21 00:00 [accepted]
PHST- 2014/04/23 06:00 [entrez]
PHST- 2014/04/23 06:00 [pubmed]
PHST- 2014/04/23 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - ijms-39-191 [pii]
PST - ppublish
SO  - Iran J Med Sci. 2014 Mar;39(2 Suppl):191-5.