PMID- 24754386
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20140423
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 77
IP  - 9-11
DP  - 2014
TI  - Relationships between persistent organic pollutants and circulating 
      immunoglobulin-Y in black-legged kittiwakes and Atlantic puffins.
PG  - 481-94
LID - 10.1080/15287394.2014.886543 [doi]
AB  - Have Although persistent organic pollutants (POPs) may affect the immune system, 
      few field studies actually examined this effect. There are indications that POP 
      exert effects on the immune system; however, in the Arctic ecosystem data are 
      scarce. The aim of this study was to examine immune functions in two medium 
      trophic-positioned seabirds, the black-legged kittiwakes (Rissa tridactyla) and 
      Atlantic puffins (Fratercula arctica). Overall POP concentrations were higher in 
      kittiwakes than puffins and males had significantly higher concentrations than 
      females. Mean concentrations of total polychlorinated biphenyls (SigmaPCB9) were 4700 
      +/- 200 and 9600 +/- 1400 ng/g lipid weight and 2800 +/- 180 and 3900 +/- 200 ng/g lipid 
      weight in female and male kittiwake and puffin blood, respectively. Levels of 
      immunoglobulin-Y (IgY) in blood of kittiwakes were not markedly affected by 
      concentrations of POP. Similarly, the primary IgY response to tetanus toxoid was 
      not affected by POP concentrations in a subsample of immunized kittiwakes. In 
      puffins, there were significant correlations between the IgY-response and some of 
      the POPs, but with low explanatory values. These results suggest that POPs 
      concentrations were lower than, or just at the threshold level for effects of the 
      proposed IgY biomarker. It is also conceivable that the IgY levels are not a 
      suitable endpoint for evaluating perturbation of the immune system in free-living 
      seabirds.
FAU - Sagerup, Kjetil
AU  - Sagerup K
AD  - a Tromso University Museum, Fram Centre , NO-9296 Tromso , Norway.
FAU - Asbakk, Kjetil
AU  - Asbakk K
FAU - Polder, Anuschka
AU  - Polder A
FAU - Skaare, Janneche U
AU  - Skaare JU
FAU - Gabrielsen, Geir W
AU  - Gabrielsen GW
FAU - Barrett, Robert T
AU  - Barrett RT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Environmental Pollutants)
RN  - 0 (IgY)
RN  - 0 (Immunoglobulins)
RN  - 0 (Tetanus Toxoid)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Charadriiformes/*blood
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*toxicity
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Immunoglobulins/*blood
MH  - Linear Models
MH  - Male
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Tetanus Toxoid/immunology
OTO - NOTNLM
OT  - Arctic
OT  - Atlantic puffin
OT  - Black-legged kittiwake
OT  - IgY
OT  - Persistent Organic Pollutants
EDAT- 2014/04/24 06:00
MHDA- 2014/06/10 06:00
CRDT- 2014/04/24 06:00
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - 10.1080/15287394.2014.886543 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2014;77(9-11):481-94. doi: 
      10.1080/15287394.2014.886543.