PMID- 24754415
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20181202
IS  - 0042-773X (Print)
IS  - 0042-773X (Linking)
VI  - 60
IP  - 2
DP  - 2014 Feb
TI  - [Dynamics of interleukin 6 levels in the patients with cardiogenic and septic 
      shock and in a control group of patients with uncomplicated AMI].
PG  - 114-22
AB  - INTRODUCTION: Cardiogenic shock (CS) is the leading cause of mortality in 
      patients with acute myocardial infarction (AMI). Inflammatory response seems to 
      be common response in patients with AMI, especially those with CS. We have 
      therefore conducted a study to determine diagnostic and prognostic utility of 
      interleukin 6 (IL6) levels in the cohort of patients with cardiogenic and septic 
      shock (SS) and in a control group of patients with uncomplicated AMI. METHODS: In 
      this prospective study 71 patients fulfilled the inclusion criteria: 30 patients 
      with cardiogenic shock, 21 patients with septic shock and 20 patients with ST 
      elevation myocardial infarction (STEMI). Plasma levels of IL6 were measured at 8 
      time points. The main endpoint was 3 month mortality. RESULTS: We have shown that 
      the highest IL6 levels during the first week were recorded in patients with 
      septic shock with peak value at admission. The maximum level of IL6 was detected 
      between 12 to 24 hours after the onset of MI among patients with cardiogenic 
      shock. According to Receiver operating characteristic (ROC) statistics levels of 
      IL6 > 357 pg/ml at admission (AUC 0.730, p = 0.031) were typical for patients 
      with CS in comparison with control group of STEMI patients. Values of IL6 > 1 237 
      pg/ml at admission and > 1 071 pg/ml at 24 hours (after admission?) were typical 
      for thouse in septic shock in comparison with CS patients. We found only a 
      non-significant trend of IL6 for the prediction of mortality in the cohort of CS 
      patients for levels 1 854 pg/ml (AUC 0.769, p = 0.066) sampled 12 hours after 
      admission. There was no association of plasma levels of IL6 with mortality in 
      septic shock patients. CONCLUSIONS: Patients with cardiogenic shock demonstrated 
      more pronounced cytokine response as evidenced by increased levels of IL6 
      compared to patients with uncomplicated STEMI. Levels of IL6 peaked in SS 
      patients at admission, in CS patients 12-24 hours after admission. In daily 
      clinical practice routine measurement of IL6 levels for prediction of prognosis 
      both in cardiogenic and septic shock are of little value mainly due to 
      significant interindividual variability of IL6 values.
FAU - Parenica, Jiri
AU  - Parenica J
FAU - Malaska, Jan
AU  - Malaska J
FAU - Jarkovsky, Jiri
AU  - Jarkovsky J
FAU - Helanova, Katerina
AU  - Helanova K
FAU - Jabandziev, Petr
AU  - Jabandziev P
FAU - Michalek, Jaroslav
AU  - Michalek J
FAU - Veselkova, Zuzana
AU  - Veselkova Z
FAU - Littnerova, Simona
AU  - Littnerova S
FAU - Kubkova, Lenka
AU  - Kubkova L
FAU - Gal, Roman
AU  - Gal R
FAU - Sevcik, Pavel
AU  - Sevcik P
FAU - Goldbergova, Monika Pavkova
AU  - Goldbergova MP
FAU - Litzman, Jiri
AU  - Litzman J
FAU - Cermakova, Zdena
AU  - Cermakova Z
FAU - Spinar, Jindrich
AU  - Spinar J
LA  - cze
PT  - Journal Article
TT  - Dynamika hladiny interleukinu 6 u pacientu v septickem a kardiogennim soku a u 
      pacientu s akutnim infarktem myokardu s elevacemi ST.
PL  - Czech Republic
TA  - Vnitr Lek
JT  - Vnitrni lekarstvi
JID - 0413602
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Prospective Studies
MH  - Shock, Cardiogenic/*blood
MH  - Shock, Septic/*blood
MH  - Time Factors
EDAT- 2014/04/24 06:00
MHDA- 2015/10/28 06:00
CRDT- 2014/04/24 06:00
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - 48441 [pii]
PST - ppublish
SO  - Vnitr Lek. 2014 Feb;60(2):114-22.