PMID- 24755035
OWN - NLM
STAT- MEDLINE
DCOM- 20141031
LR  - 20220409
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 13
DP  - 2014 Apr 23
TI  - Impact of serum omentin-1 levels on cardiac prognosis in patients with heart 
      failure.
PG  - 84
LID - 10.1186/1475-2840-13-84 [doi]
AB  - BACKGROUND: Various adipokines are reported to be associated with the development 
      of heart failure (HF) through insulin resistance and chronic inflammation. 
      Omentin-1 is a novel adipokine and is associated with incident coronary artery 
      disease. However, it remains unclear whether serum omentin-1 levels are 
      associated with cardiac prognosis in patients with HF. METHODS: We measured serum 
      omentin-1 levels at admission in 136 consecutive patients with HF, and 20 control 
      subjects without signs of significant heart disease. We prospectively followed 
      patients with HF to endpoints of cardiac death or re-hospitalization for 
      worsening HF. RESULTS: Serum omentin-1 levels were markedly lower in HF patients 
      with cardiac events compared with to without. The patients who were in New York 
      Heart Association (NYHA) functional class IV showed significantly lower serum 
      omentin-1 levels compared to those in class II and III, whereas serum omentin-1 
      levels did not correlate with serum brain natriuretic peptide levels (r = 0.217, 
      P = 0.011). We divided the HF patients into three groups based on the tertiles of 
      serum omentin-1 level (low T1, middle T2, and high T3). Multivariate Cox hazard 
      analysis showed that the lowest serum omentin-1 level (T1) was independently 
      associated with cardiac events after adjustment for confounding factors (hazard 
      ratio 5.78, 95% confidence interval 1.20-12.79). We divided the HF patients into 
      two groups according to the median serum omentin-1 levels. Kaplan-Meier analysis 
      revealed that the patients with low serum omentin-1 levels had a higher risk of 
      cardiac events compared with those with high serum omentin-1 levels (log-rank 
      test p < 0.001). CONCLUSION: Decreased serum omentin-1 levels were associated 
      with a poor cardiac outcome in patients with HF.
FAU - Narumi, Taro
AU  - Narumi T
FAU - Watanabe, Tetsu
AU  - Watanabe T
AD  - Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School 
      of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan. 
      tewatana@med.id.yamagata-u.ac.jp.
FAU - Kadowaki, Shinpei
AU  - Kadowaki S
FAU - Kinoshita, Daisuke
AU  - Kinoshita D
FAU - Yokoyama, Miyuki
AU  - Yokoyama M
FAU - Honda, Yuki
AU  - Honda Y
FAU - Otaki, Yoichiro
AU  - Otaki Y
FAU - Nishiyama, Satoshi
AU  - Nishiyama S
FAU - Takahashi, Hiroki
AU  - Takahashi H
FAU - Arimoto, Takanori
AU  - Arimoto T
FAU - Shishido, Tetsuro
AU  - Shishido T
FAU - Miyamoto, Takuya
AU  - Miyamoto T
FAU - Kubota, Isao
AU  - Kubota I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (ITLN1 protein, human)
RN  - 0 (Lectins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - GPI-Linked Proteins/blood
MH  - Heart Failure/*blood/*diagnosis
MH  - Humans
MH  - Lectins/*blood
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC4006671
EDAT- 2014/04/24 06:00
MHDA- 2014/11/02 06:00
PMCR- 2014/04/23
CRDT- 2014/04/24 06:00
PHST- 2014/03/04 00:00 [received]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2014/11/02 06:00 [medline]
PHST- 2014/04/23 00:00 [pmc-release]
AID - 1475-2840-13-84 [pii]
AID - 10.1186/1475-2840-13-84 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2014 Apr 23;13:84. doi: 10.1186/1475-2840-13-84.