PMID- 24755250
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 14
DP  - 2014 Apr 23
TI  - Morus alba L. suppresses the development of atopic dermatitis induced by the 
      house dust mite in NC/Nga mice.
PG  - 139
LID - 10.1186/1472-6882-14-139 [doi]
AB  - BACKGROUND: Morus alba, a medicinal plant in Asia, has been used traditionally to 
      treat diabetes mellitus and hypoglycemia. However, the effects of M. alba extract 
      (MAE) on atopic dermatitis have not been verified scientifically. We investigated 
      the effects of MAE on atopic dermatitis through in vitro and in vivo experiments. 
      METHODS: We evaluated the effects of MAE on the production of nitric oxide (NO) 
      and prostaglandin E2 (PGE2) in RAW 264.7, as well as thymus and 
      activation-regulated chemokine (TARC/CCL17) in HaCaT cells. In an in vivo 
      experiment, atopic dermatitis was induced by topical application of house dust 
      mites for four weeks, and the protective effects of MAE were investigated by 
      measuring the severity of the skin reaction on the back and ears, the plasma 
      levels of immunoglobulin E (IgE) and histamine, and histopathological changes in 
      the skin on the back and ears. RESULTS: MAE suppressed the production of NO and 
      PGE2 in RAW 264.7 cells, as well as TARC in HaCaT cells, in a dose-dependent 
      manner. MAE treatment of NC/Nga mice reduced the severity of dermatitis and the 
      plasma levels of IgE and histamine. MAE also reduced the histological 
      manifestations of atopic dermatitis-like skin lesions such as erosion, 
      hyperplasia of the epidermis and dermis, and inflammatory cell infiltration in 
      the skin on the back and ears. CONCLUSION: Our results suggest that MAE has 
      potent inhibitory effects on atopic dermatitis-like lesion and may be a 
      beneficial natural resource for the treatment of atopic dermatitis.
FAU - Lim, Hye-Sun
AU  - Lim HS
FAU - Ha, Hyekyung
AU  - Ha H
FAU - Lee, Hoyoung
AU  - Lee H
FAU - Lee, Jun Kyung
AU  - Lee JK
FAU - Lee, Mee-Young
AU  - Lee MY
FAU - Shin, Hyeun-Kyoo
AU  - Shin HK
AD  - Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, 
      1672 Yuseong-daero, Yuseong-gu, Daejeon 305-811, Republic of Korea. 
      hkshin@kiom.re.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Chemokine CCL17)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Chemokine CCL17/immunology
MH  - Dermatitis, Atopic/*drug therapy/immunology/prevention & control
MH  - Disease Models, Animal
MH  - Histamine/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mice
MH  - Morus/*chemistry
MH  - Plant Extracts/*administration & dosage
MH  - Pyroglyphidae/*immunology
MH  - Skin/drug effects/enzymology
PMC - PMC4003291
EDAT- 2014/04/24 06:00
MHDA- 2015/07/08 06:00
PMCR- 2014/04/23
CRDT- 2014/04/24 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2014/04/16 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
PHST- 2014/04/23 00:00 [pmc-release]
AID - 1472-6882-14-139 [pii]
AID - 10.1186/1472-6882-14-139 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2014 Apr 23;14:139. doi: 10.1186/1472-6882-14-139.