PMID- 24755352
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 75
IP  - 7
DP  - 2014 Jul
TI  - Killer cell immunoglobulin-like receptors in Thai patients with leukemia and 
      diffuse large B-cell lymphoma.
PG  - 673-6
LID - S0198-8859(14)00115-3 [pii]
LID - 10.1016/j.humimm.2014.04.004 [doi]
AB  - Natural killer (NK) cells are key components of the innate immune system that 
      have been implicated in the immune response against tumor cells. Killer cell 
      immunoglobulin-like receptors (KIR) regulate NK cell activity by interaction with 
      specific human leukocyte antigen (HLA) class I. In this study, KIR gene 
      polymorphisms and their HLA ligands were investigated in Thai patients with 
      chronic myelogenous leukemia (CML) (n=60), acute myelogenous leukemia (AML) 
      (n=60), acute lymphoblastic leukemia (ALL) (n=55), and diffuse large B-cell 
      lymphoma (DLBCL) (n=60) compared with 150 healthy controls. The frequency of 
      KIR3DL1 with HLA-Bw4 was significantly lower in DLBCL patients than in controls 
      (P=0.0006, Pc=0.02), whereas no significant differences were seen in KIR gene 
      frequencies and their ligands between leukemia patients and controls. This study 
      suggest a role of inhibitory KIR with its ligand in the protection against DLBCL.
CI  - Copyright (c) 2014 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Vejbaesya, Sasijit
AU  - Vejbaesya S
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Bangkok, Thailand. Electronic address: sasijit.vej@mahidol.ac.th.
FAU - Sae-Tam, Pradermchai
AU  - Sae-Tam P
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Bangkok, Thailand.
FAU - Khuhapinant, Archrob
AU  - Khuhapinant A
AD  - Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
FAU - Srinak, Duangporn
AU  - Srinak D
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Bangkok, Thailand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140419
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-Bw4 antigen)
RN  - 0 (KIR3DL1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR3DL1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - HLA-B Antigens/*genetics/immunology
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL 
      Positive/ethnology/*genetics/immunology/pathology
MH  - Leukemia, Myeloid, Acute/ethnology/*genetics/immunology/pathology
MH  - Ligands
MH  - Lymphoma, Large B-Cell, Diffuse/ethnology/*genetics/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Precursor Cell Lymphoblastic 
      Leukemia-Lymphoma/ethnology/*genetics/immunology/pathology
MH  - Receptors, KIR3DL1/*genetics/immunology
MH  - Thailand
OTO - NOTNLM
OT  - DLBCL
OT  - KIR
OT  - Leukemia
OT  - Thai
EDAT- 2014/04/24 06:00
MHDA- 2015/01/23 06:00
CRDT- 2014/04/24 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2014/01/06 00:00 [revised]
PHST- 2014/04/06 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
AID - S0198-8859(14)00115-3 [pii]
AID - 10.1016/j.humimm.2014.04.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2014 Jul;75(7):673-6. doi: 10.1016/j.humimm.2014.04.004. Epub 2014 
      Apr 19.