PMID- 24755993
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20220330
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 4
IP  - 4
DP  - 2014 Apr 22
TI  - Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact 
      on therapy-induced change in real-life positive affective experiences?
PG  - e384
LID - 10.1038/tp.2014.23 [doi]
AB  - Positive affect (PA) has an important role in resilience against depression and 
      has been shown to increase with mindfulness-based cognitive therapy (MBCT). To 
      elucidate the underlying mechanisms of change in PA as well as develop insights 
      that may benefit personalized medicine, the current study examined the 
      contribution of genetic variation to individual differences in change in PA in 
      response to MBCT. Individuals (n=126) with residual depressive symptoms were 
      randomized to either an MBCT group or treatment as usual. PA was assessed using 
      experience sampling methodology (ESM). Single-nucleotide polymorphisms (SNPs) in 
      genes known to be involved in reward functioning were selected. SNPs in the genes 
      for brain-derived neurotrophic factor (BDNF), the muscarinic acetylcholine 
      receptor M2 (CHRM2), the dopamine receptor D4 (DRD4) and the mu1 opioid receptor 
      (OPRM1) significantly moderated the impact of treatment condition over time on 
      PA. Genetic variation in the genes for CHRM2 and OPRM1 specifically had an impact 
      on the level of PA following MBCT. The current study shows that variation in 
      response to MBCT may be contingent on genetic factors associated with the 
      regulation of PA. These findings contribute to our understanding of the processes 
      moderating response to treatment and prediction of treatment outcome.
FAU - Bakker, J M
AU  - Bakker JM
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Lieverse, R
AU  - Lieverse R
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Menne-Lothmann, C
AU  - Menne-Lothmann C
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Viechtbauer, W
AU  - Viechtbauer W
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Pishva, E
AU  - Pishva E
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Kenis, G
AU  - Kenis G
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - Geschwind, N
AU  - Geschwind N
AD  - Department of Clinical Psychological Science, Faculty of Psychology and 
      Neuroscience, Maastricht University, Maastricht, The Netherlands.
FAU - Peeters, F
AU  - Peeters F
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
FAU - van Os, J
AU  - van Os J
AD  - 1] Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands 
      [2] Department of Psychosis Studies, Institute of Psychiatry, King's College, 
      King's Health Partners, London, UK.
FAU - Wichers, M
AU  - Wichers M
AD  - Department of Psychiatry and Psychology, School of Mental Health and 
      Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140422
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
SB  - IM
MH  - Affect/*physiology
MH  - Cognitive Behavioral Therapy/*methods
MH  - Depression/*genetics/*therapy
MH  - Human Activities/*psychology
MH  - Humans
MH  - Individuality
MH  - Mindfulness/methods
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Treatment Outcome
PMC - PMC4012287
EDAT- 2014/04/24 06:00
MHDA- 2015/03/07 06:00
PMCR- 2014/04/01
CRDT- 2014/04/24 06:00
PHST- 2013/09/05 00:00 [received]
PHST- 2014/03/05 00:00 [revised]
PHST- 2014/03/08 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - tp201423 [pii]
AID - 10.1038/tp.2014.23 [doi]
PST - epublish
SO  - Transl Psychiatry. 2014 Apr 22;4(4):e384. doi: 10.1038/tp.2014.23.