PMID- 24756045
OWN - NLM
STAT- MEDLINE
DCOM- 20150302
LR  - 20140709
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 27
IP  - 7-8
DP  - 2014 Jul
TI  - A rare case of hypoglycaemia due to insulinoma in an adolescent with acutely 
      altered mental status.
PG  - 773-6
LID - 10.1515/jpem-2013-0353 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is an inherited neoplasia 
      syndrome that generally presents with hypercalcaemia due to hyperparathyroidism. 
      Insulin-producing tumours are less common components of the syndrome that emerge 
      later during the course of the disease. We report here a case of an adolescent 
      who presented with symptomatic hypoglycaemia as the first indication of MEN1. 
      CASE: A 14-year-old boy, known to use illicit drugs, was brought to the hospital 
      with altered mental status. He was hypoglycaemic and further investigations 
      revealed two pancreatic insulinomas. Despite having no relevant family history, 
      genetic evaluation showed a mutation consistent with MEN1. CONCLUSION: 
      Insulinomas in adolescents are generally rare and even less common as a first 
      presentation of MEN1. This diagnosis carries implications for potential future 
      neoplasms, both benign and malignant. While intoxication is a more common case of 
      altered mental status in adolescents, clinicians must maintain a high index of 
      suspicion for organic disease.
FAU - Winston, Karin Y
AU  - Winston KY
FAU - Dawrant, Jonathan
AU  - Dawrant J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Hyperinsulinism/complications
MH  - Hypoglycemia/*etiology
MH  - Insulinoma/*complications/surgery
MH  - Male
MH  - Mental Disorders/etiology
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Pancreatic Neoplasms/*complications/surgery
EDAT- 2014/04/24 06:00
MHDA- 2015/03/03 06:00
CRDT- 2014/04/24 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2014/02/28 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/03/03 06:00 [medline]
AID - /j/jpem.ahead-of-print/jpem-2013-0353/jpem-2013-0353.xml [pii]
AID - 10.1515/jpem-2013-0353 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2014 Jul;27(7-8):773-6. doi: 10.1515/jpem-2013-0353.