PMID- 24756223
OWN - NLM
STAT- MEDLINE
DCOM- 20150410
LR  - 20211021
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 35
IP  - 6
DP  - 2014 Aug
TI  - The influence of human leukocyte antigen matching on outcomes in pediatric heart 
      transplantation.
PG  - 1020-3
LID - 10.1007/s00246-014-0890-x [doi]
AB  - Previous adult heart transplantation studies have demonstrated that 
      donor-recipient human leukocyte antigen (HLA) matching results in reduced graft 
      failure and improved patient survival. No study has examined these effects in 
      children. This study investigated the effect of HLA matching on outcomes in 
      pediatric heart transplantation. All pediatric heart transplantation data for 
      patients 0-18 years of age available from the United Network for Organ Sharing 
      Transplant Registry from 1987 to 2009 were analyzed retrospectively. 
      Donor-recipient HLA matching at loci A, B, and DR (0-6) was compared with graft 
      survival and recipient survival. For this study, 3,751 pediatric cardiac 
      transplantation events with complete HLA matching data were identified and 
      grouped as having 0 to 2 matches (3,416 events) or 3 to 6 matches (335 events). 
      The 3- to 6-match group had less graft failure than the 0- to 2-match group 
      (28.7% vs 34.4%; p = 0.035) and greater patient survival by 5 years (81% vs 72%; 
      p = 0.045) and 10 years (66% vs 55%; p = 0.005) after transplantation. The HLA-DR 
      matching alone resulted in less graft failure (p = 0.038) and improved patient 
      survival (p = 0.017). A higher degree of HLA matching in pediatric heart 
      transplantation is associated with decreased graft failure and improved patient 
      survival. In this study, decreased graft failure rates and superior survival also 
      were seen with DR matching alone.
FAU - Ginde, Salil
AU  - Ginde S
AD  - Division of Pediatric Cardiology, Department of Pediatrics, Medical College of 
      Wisconsin, 9000 W. Wisconsin Avenue, MS 713, Milwaukee, WI, 53226, USA, 
      sginde@chw.org.
FAU - Ellis, Thomas M
AU  - Ellis TM
FAU - Nugent, Melodee
AU  - Nugent M
FAU - Simpson, Pippa
AU  - Simpson P
FAU - Stendahl, Gail
AU  - Stendahl G
FAU - Berger, Stuart
AU  - Berger S
FAU - Zangwill, Steven
AU  - Zangwill S
LA  - eng
PT  - Journal Article
DEP - 20140423
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Child, Preschool
MH  - Female
MH  - Graft Survival/*immunology
MH  - HLA Antigens/*immunology
MH  - Heart Diseases/surgery
MH  - *Heart Transplantation/methods/mortality/statistics & numerical data
MH  - Histocompatibility
MH  - Histocompatibility Testing/methods/statistics & numerical data
MH  - Humans
MH  - Infant, Newborn
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Proportional Hazards Models
MH  - Registries
MH  - Retrospective Studies
MH  - United States/epidemiology
EDAT- 2014/04/24 06:00
MHDA- 2015/04/11 06:00
CRDT- 2014/04/24 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2015/04/11 06:00 [medline]
AID - 10.1007/s00246-014-0890-x [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2014 Aug;35(6):1020-3. doi: 10.1007/s00246-014-0890-x. Epub 2014 
      Apr 23.