PMID- 24756482
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20221207
IS  - 1178-1653 (Print)
IS  - 1178-1653 (Linking)
VI  - 7
IP  - 3
DP  - 2014
TI  - Does diabetes have an impact on health-state utility? a study of Asians in 
      Singapore.
PG  - 329-37
LID - 10.1007/s40271-014-0059-y [doi]
AB  - OBJECTIVE: Our objective was to compare the time trade-off (TTO) values of 
      EQ-5D-3L health states elicited from Singaporeans with and without type 2 
      diabetes mellitus (T2DM) and T2DM patients with and without complications. 
      METHODS: The TTO values of ten EQ-5D-3L health states were elicited from a 
      consecutive sample of T2DM patients and a general Singaporean population sample 
      using similar valuation protocols. In face-to-face interviews, T2DM patients and 
      members of the general population were asked to value five and ten health states, 
      respectively. The difference in TTO values between the two samples and between 
      T2DM patients with and without complications was examined using multiple linear 
      regression models. RESULTS: A total of 109 T2DM patients and 46 individuals 
      without T2DM provided data. All ten health states considered, the mean TTO value 
      was -0.02 for the general population sample and -0.04 for T2DM patients, with the 
      unadjusted and adjusted difference being -0.06 (95 % confidence interval [CI] 
      -0.16, 0.03) and 0.02 (95 % CI -0.12, 0.15). The general population sample had 
      systematically lower TTO values for mild health states, with the adjusted 
      difference being -0.13 (95 % CI -0.25, -0.02); while the two samples had similar 
      TTO values for severe health states, with the adjusted difference being 0.02 
      (95 % CI -0.16, 0.19). T2DM patients without complications had systematically 
      lower TTO values than those with complications, with the adjusted difference 
      being -0.10 (95 % CI -0.23, 0.03). CONCLUSIONS: It appears that diabetes and its 
      complications affect patients' valuation of health states. Hence, the EQ-5D-3L 
      health-state values based on the general population may underestimate the utility 
      of health interventions for T2DM.
FAU - Wang, P
AU  - Wang P
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 16 
      Medical Drive, Block MD3, Singapore, 117597, Singapore.
FAU - Tai, E S
AU  - Tai ES
FAU - Thumboo, J
AU  - Thumboo J
FAU - Vrijhoef, Hubertus J M
AU  - Vrijhoef HJ
FAU - Luo, Nan
AU  - Luo N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Patient
JT  - The patient
JID - 101309314
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Asian People/*psychology
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/complications/*psychology
MH  - Educational Status
MH  - Female
MH  - Glycated Hemoglobin
MH  - *Health Status
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Singapore
MH  - Surveys and Questionnaires
EDAT- 2014/04/24 06:00
MHDA- 2014/10/15 06:00
CRDT- 2014/04/24 06:00
PHST- 2014/04/24 06:00 [entrez]
PHST- 2014/04/24 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.1007/s40271-014-0059-y [doi]
PST - ppublish
SO  - Patient. 2014;7(3):329-37. doi: 10.1007/s40271-014-0059-y.