PMID- 24758161
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20240321
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Apr 23
TI  - Long term effects of cocaine on the heart assessed by cardiovascular magnetic 
      resonance at 3T.
PG  - 26
LID - 10.1186/1532-429X-16-26 [doi]
AB  - BACKGROUND: Cocaine is an addictive, sympathomimetic drug with potentially lethal 
      effects. The prevalence and features of cocaine cardiotoxicity are not well 
      known. We aimed to assess these effects using a comprehensive cardiovascular 
      magnetic resonance (CMR) protocol in a large group of asymptomatic cocaine users. 
      METHODS: Consecutive (n = 94, 81 males, 36.6 +/-7 years), non-selected, cocaine 
      abusers were recruited and had a medical history, examination, ECG, blood test 
      and CMR. The CMR study included measurement of left and right ventricular (LV, 
      RV) dimensions and ejection fraction (EF), sequences for detection of myocardial 
      oedema and late gadolinium enhancement (LGE). Images were compared to a cohort of 
      healthy controls. RESULTS: Years of regular cocaine use were 13.9 +/- 9. When 
      compared to the age-matched healthy cohort, the cocaine abusers had increased LV 
      end-systolic volume, LV mass index and RV end-systolic volume, with decreased 
      LVEF and RVEF. No subject had myocardial oedema, but 30% had myocardial LGE 
      indicating myocardial damage. CONCLUSIONS: CMR detected cardiovascular disease in 
      71% of this cohort of consecutive asymptomatic cocaine abusers and mean duration 
      of abuse was related to probability of LV systolic dysfunction.
FAU - Maceira, Alicia M
AU  - Maceira AM
FAU - Ripoll, Carmen
AU  - Ripoll C
FAU - Cosin-Sales, Juan
AU  - Cosin-Sales J
FAU - Igual, Begona
AU  - Igual B
FAU - Gavilan, Mirella
AU  - Gavilan M
FAU - Salazar, Jose
AU  - Salazar J
FAU - Belloch, Vicente
AU  - Belloch V
FAU - Pennell, Dudley J
AU  - Pennell DJ
AD  - NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital & Imperial 
      College, London, UK. d.pennell@ic.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20140423
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Asymptomatic Diseases
MH  - Case-Control Studies
MH  - Cocaine-Related Disorders/*complications
MH  - Contrast Media
MH  - Edema, Cardiac/diagnosis/etiology/pathology
MH  - Electrocardiography
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/*diagnosis/etiology/pathology/physiopathology
MH  - Ventricular Dysfunction, Right/*diagnosis/etiology/pathology/physiopathology
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
MH  - Young Adult
PMC - PMC4026110
EDAT- 2014/04/25 06:00
MHDA- 2014/10/22 06:00
PMCR- 2014/04/23
CRDT- 2014/04/25 06:00
PHST- 2013/09/15 00:00 [received]
PHST- 2014/03/24 00:00 [accepted]
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
PHST- 2014/04/23 00:00 [pmc-release]
AID - S1097-6647(23)00086-8 [pii]
AID - 1532-429X-16-26 [pii]
AID - 10.1186/1532-429X-16-26 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2014 Apr 23;16(1):26. doi: 10.1186/1532-429X-16-26.