PMID- 24758208
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220331
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 2
DP  - 2014 Aug
TI  - HLA-G 3' untranslated region polymorphisms influence the susceptibility for human 
      papillomavirus infection.
PG  - 216-22
LID - 10.1111/tan.12359 [doi]
AB  - Human leukocyte antigen (HLA)-G molecule acts as a potential factor for the 
      regulation of immune responses and its expression in virus-infected cells may 
      enable them to escape immunosurveillance. Besides its polymorphic promoter 
      region, the 3' untranslated region (UTR) seems to play an important role in 
      regulating HLA-G expression. In this study, we investigated the influence of 
      HLA-G 14 bp (rs66554220) and +3142 (rs1063320) polymorphisms in 179 women with 
      active human papillomavirus (HPV) infection and 143 age-matched, unrelated, 
      HPV-negative, normal Chinese Han population. Our findings showed that frequency 
      of the allele +3142 C [31.3% vs 44.4%, odds ratio (OR) = 0.57, Pc < 0.01] and the 
      genotype +3142 CC (10.6% vs 21.7%, OR = 0.43, Pc = 0.012) was significantly 
      decreased in HPV infected patients compared with normal controls. Furthermore, 
      the haplotype -14 bp/C was associated with a reduced risk for HPV infection (OR = 
      0.57, Pc = 0.001). Our findings also showed that HLA-G homozygous +14 bp/+14 bp 
      genotype was significantly associated with an increased risk for HPV18 infection 
      (OR = 12.95, P < 0.01), whereas HLA-G heterozygous +14 bp/-14 bp genotype 
      increased risk for HPV58 (OR = 5.55, P < 0.05). Furthermore, frequency of the 
      haplotype +14 bp/G was significantly increased in HPV18 infected patients (60.0% 
      vs 27.3%, OR = 4.00, Pc < 0.05). Taken together, our results supported a role of 
      the HLA-G 3' UTR polymorphisms as a susceptible factor for the active HPV 
      infection, and suggested a possible interference of the HLA-G molecule in the 
      response to virus infection.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Xu, H-H
AU  - Xu HH
AD  - Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      University, Linhai, China.
FAU - Shi, W-W
AU  - Shi WW
FAU - Lin, A
AU  - Lin A
FAU - Yan, W-H
AU  - Yan WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (3' Untranslated Regions)
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - 3' Untranslated Regions/*genetics
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Middle Aged
MH  - Papillomaviridae/classification/physiology
MH  - Papillomavirus Infections/*genetics/*immunology/virology
MH  - *Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - active infection
OT  - human leukocyte antigen-G
OT  - human papillomavirus
OT  - polymorphism
EDAT- 2014/04/25 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/04/25 06:00
PHST- 2013/11/28 00:00 [received]
PHST- 2014/03/04 00:00 [revised]
PHST- 2014/03/25 00:00 [accepted]
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1111/tan.12359 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Aug;84(2):216-22. doi: 10.1111/tan.12359. Epub 2014 Apr 23.