PMID- 24758519
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20201226
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 10
IP  - 7
DP  - 2014 Jul
TI  - Crosstalk between dendritic cell subsets and implications for dendritic 
      cell-based anticancer immunotherapy.
PG  - 915-26
LID - 10.1586/1744666X.2014.912561 [doi]
AB  - Dendritic cells (DCs) are a family of professional antigen-presenting cells that 
      have an indispensable role in the initiation of innate and adaptive immune 
      responses against pathogens and tumor cells. The DC family is very heterogeneous. 
      Two main types of naturally occurring DCs circulate in peripheral blood, each 
      with its unique phenotypic and functional characteristics: myeloid DCs and 
      plasmacytoid. There is an ample number of studies that have focused on the 
      bi-directional crosstalk between DCs and natural killer cells or T cells. 
      However, the crosstalk among the different DC subsets, in the context of 
      infectious diseases and cancer, has until now not received much attention. Here, 
      we review all available literature that has dealt with the crosstalk between 
      plasmacytoid and myeloid DCs and the potential mode of action. Emphasis will be 
      given to the therapeutic potential of the combination of DC subsets for DC-based 
      immunotherapy.
FAU - Bakdash, Ghaith
AU  - Bakdash G
AD  - Department of Tumor Immunology, Radboud University Medical Centre and Radboud 
      Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
FAU - Schreurs, Inge
AU  - Schreurs I
FAU - Schreibelt, Gerty
AU  - Schreibelt G
FAU - Tel, Jurjen
AU  - Tel J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140423
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
SB  - IM
MH  - Dendritic Cells/*metabolism/*transplantation
MH  - Humans
MH  - *Immunotherapy
MH  - Neoplasms/*therapy
OTO - NOTNLM
OT  - cancer
OT  - crosstalk
OT  - immunotherapy
OT  - myeloid DCs
OT  - plasmacytoid DCs
EDAT- 2014/04/25 06:00
MHDA- 2015/02/14 06:00
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - 10.1586/1744666X.2014.912561 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2014 Jul;10(7):915-26. doi: 
      10.1586/1744666X.2014.912561. Epub 2014 Apr 23.