PMID- 24758732
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140909
LR  - 20211021
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Apr
TI  - Local expression of interleukin-17a is correlated with nasal eosinophilia and 
      clinical severity in allergic rhinitis.
PG  - 22-7
LID - 10.2500/ar.2014.5.0078 [doi]
AB  - Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are 
      associated with chronic inflammations. The local expression of IL-17A in allergic 
      rhinitis (AR) remains to be characterized. We sought to determine the role of 
      IL-17A expression in human inferior turbinate mucosa in the pathophysiology of 
      AR. Inferior turbinate mucosa was sampled from medical treatment-resistant, 
      surgery-required patients with perennial AR (PAR, n = 21), nonallergic rhinitis 
      with eosinophilia syndrome (NARES, n = 7), and nonallergic hypertrophic rhinitis 
      (HR, n = 13). IL-17A expression was determined with immunohistochemical staining. 
      The mean number of IL-17A(+) cells and eosinophils per field were counted. Total 
      serum immunoglobulin E (IgE) levels, blood eosinophil count, and forced 
      expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio were also 
      examined in each patient. IL-17A was primarily expressed in infiltrating 
      inflammatory cells. The number of IL-17A(+) cells in nasal mucosa was 
      significantly higher in the PAR group compared with HR (p = 0.002) and NARES (p = 
      0.021) groups. There was a significant and positive correlation between the 
      number of IL-17A(+) cells and total nasal symptom score (rho = 0.403; p = 0.011), 
      especially sneezing score (rho = 0.471; p = 0.003). The number of IL-17A(+) cells 
      was significantly and positively correlated with the degree of eosinophil 
      infiltration (rho = 0.623; p < 0.001), but not with total serum IgE levels (rho = 
      0.284; p = 0.098), blood eosinophil counts (rho = 0.302; p = 0.056), or FEV1/FVC 
      ratio (rho = 0.092; p = 0.569). The present study provides evidence that IL-17A 
      expression in the nasal mucosa is associated with the pathophysiology of AR, 
      including disease severity and nasal eosinophilia.
FAU - Makihara, Seiichiro
AU  - Makihara S
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Okano, Mitsuhiro
AU  - Okano M
FAU - Fujiwara, Tazuko
AU  - Fujiwara T
FAU - Noda, Yohei
AU  - Noda Y
FAU - Higaki, Takaya
AU  - Higaki T
FAU - Miyateke, Tomomi
AU  - Miyateke T
FAU - Kanai, Kengo
AU  - Kanai K
FAU - Haruna, Takenori
AU  - Haruna T
FAU - Kariya, Shin
AU  - Kariya S
FAU - Nishizaki, Kazunori
AU  - Nishizaki K
LA  - eng
PT  - Journal Article
DEP - 20140422
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC4019741
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2014/04/25 06:00
MHDA- 2014/04/25 06:01
PMCR- 2014/03/01
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/04/25 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - content-0078 [pii]
AID - AR043-12 [pii]
AID - 10.2500/ar.2014.5.0078 [doi]
PST - ppublish
SO  - Allergy Rhinol (Providence). 2014 Apr;5(1):22-7. doi: 10.2500/ar.2014.5.0078. 
      Epub 2014 Apr 22.