PMID- 24759101
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20211021
IS  - 1083-351X (Electronic)
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 289
IP  - 24
DP  - 2014 Jun 13
TI  - A molecular basis for the interplay between T cells, viral mutants, and human 
      leukocyte antigen micropolymorphism.
PG  - 16688-98
LID - 10.1074/jbc.M114.563502 [doi]
AB  - Mutations within T cell epitopes represent a common mechanism of viral escape 
      from the host protective immune response. The diverse T cell repertoire and the 
      extensive human leukocyte antigen (HLA) polymorphism across populations is the 
      evolutionary response to viral mutation. However, the molecular basis 
      underpinning the interplay between HLA polymorphism, the T cell repertoire, and 
      viral escape is unclear. Here we investigate the T cell response to a 
      HLA-B*35:01- and HLA-B*35:08-restricted (407)HPVGEADYFEY(417) epitope from 
      Epstein-Barr virus and naturally occurring variants at positions 4 and 5 thereof. 
      Each viral variant differently impacted on the epitope's flexibility and 
      conformation when bound to HLA-B*35:08 or HLA-B*35:01. We provide a molecular 
      basis for understanding how the single residue polymorphism that discriminates 
      between HLA-B*35:01/08 profoundly impacts on T cell receptor recognition. 
      Surprisingly, one viral variant (P5-Glu to P5-Asp) effectively changed 
      restriction preference from HLA-B*35:01 to HLA-B*35:08. Collectively, our study 
      portrays the interplay between the T cell response, viral escape, and HLA 
      polymorphism, whereby HLA polymorphism enables altered presentation of epitopes 
      from different strains of Epstein-Barr virus.
CI  - (c) 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
FAU - Liu, Yu Chih
AU  - Liu YC
AD  - From the Department of Biochemistry and Molecular Biology, School of Biomedical 
      Sciences, Monash University, Clayton, Melbourne 3800, Australia.
FAU - Chen, Zhenjun
AU  - Chen Z
AD  - Department of Microbiology and Immunology, Peter Doherty Institute for Infection 
      and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Neller, Michelle A
AU  - Neller MA
AD  - QIMR Berghofer Medical Research Institute and QIMR Berghofer Centre for 
      Immunotherapy and Vaccine Development, Brisbane, Queensland 4006, Australia.
FAU - Miles, John J
AU  - Miles JJ
AD  - QIMR Berghofer Medical Research Institute and QIMR Berghofer Centre for 
      Immunotherapy and Vaccine Development, Brisbane, Queensland 4006, Australia.
FAU - Purcell, Anthony W
AU  - Purcell AW
AD  - From the Department of Biochemistry and Molecular Biology, School of Biomedical 
      Sciences, Monash University, Clayton, Melbourne 3800, Australia.
FAU - McCluskey, James
AU  - McCluskey J
AD  - Department of Microbiology and Immunology, Peter Doherty Institute for Infection 
      and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Burrows, Scott R
AU  - Burrows SR
AD  - QIMR Berghofer Medical Research Institute and QIMR Berghofer Centre for 
      Immunotherapy and Vaccine Development, Brisbane, Queensland 4006, Australia.
FAU - Rossjohn, Jamie
AU  - Rossjohn J
AD  - From the Department of Biochemistry and Molecular Biology, School of Biomedical 
      Sciences, Monash University, Clayton, Melbourne 3800, Australia, Institute of 
      Infection and Immunity, Cardiff University School of Medicine, Heath Park, 
      Cardiff, CF14 4XN Wales, United Kingdom, and Australian Research Council Centre 
      of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 
      3800, Australia jamie.rossjohn@monash.edu.
FAU - Gras, Stephanie
AU  - Gras S
AD  - From the Department of Biochemistry and Molecular Biology, School of Biomedical 
      Sciences, Monash University, Clayton, Melbourne 3800, Australia, Australian 
      Research Council Centre of Excellence in Advanced Molecular Imaging, Monash 
      University, Clayton, Victoria 3800, Australia stephanie.gras@monash.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Epitopes)
RN  - 0 (HLA-B*35:01 antigen)
RN  - 0 (HLA-B35 Antigen)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Epitopes/chemistry/genetics
MH  - HLA-B35 Antigen/*chemistry/genetics
MH  - Herpesvirus 4, Human/*genetics/immunology
MH  - Humans
MH  - Molecular Docking Simulation
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - Protein Conformation
MH  - Receptors, Antigen, T-Cell/*chemistry/genetics
MH  - T-Lymphocytes/immunology
PMC - PMC4059114
OTO - NOTNLM
OT  - Immunology
OT  - Major Histocompatibility Complex (MHC)
OT  - Structural Biology
OT  - T Cell Receptor (TCR)
OT  - X-ray Crystallography
EDAT- 2014/04/25 06:00
MHDA- 2014/10/25 06:00
PMCR- 2015/06/13
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
PHST- 2015/06/13 00:00 [pmc-release]
AID - S0021-9258(20)40643-X [pii]
AID - M114.563502 [pii]
AID - 10.1074/jbc.M114.563502 [doi]
PST - ppublish
SO  - J Biol Chem. 2014 Jun 13;289(24):16688-98. doi: 10.1074/jbc.M114.563502. Epub 
      2014 Apr 23.