PMID- 24760117
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220331
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 47
IP  - 5
DP  - 2014 May
TI  - Oxidative stress and cellular immunity in patients with recurrent aphthous 
      ulcers.
PG  - 355-60
LID - S0100-879X2014005043714 [pii]
AB  - Recurrent aphthous ulcer (RAU) is an inflammatory condition of the oral mucosa 
      characterized by painful, well-circumscribed, single or multiple round or ovoid 
      ulcerations. The exact etiologic factor(s) of these ulcerations are not yet 
      understood. The objective of this study was to evaluate inflammatory processes 
      and free radical metabolism of 25 patients with RAUs compared to 25 healthy 
      controls. The levels of malondialdehyde (MDA) and glutathione (GSH) were 
      determined by high-performance liquid chromatography. Tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-2 (IL-2), IL-10, and IL-12 were determined by ELISA. Nitric 
      oxide (NO), myeloperoxidase (MPO), total antioxidant status (TAS), and total 
      oxidant status (TOS) levels were measured spectroscopically in serum. The levels 
      of MDA, GSH, TNF-alpha, IL-2, IL-12, MPO, and TOS, and oxidative stress index (OSI) 
      were higher, and the levels of NO, IL-10, and TAS were lower in patients with RAU 
      than in controls. Statistical analysis showed that GSH, TNF-alpha, IL-2, IL-10, and 
      OSI differed significantly in patients with RAU compared to controls. These 
      parameters have important roles in oxidant/antioxidant defense.
FAU - Avci, E
AU  - Avci E
AD  - Department of Molecular Biology and Genetics/Biochemistry, Faculty of Science and 
      Arts, Hitit University, Corum, Turkey.
FAU - Akarslan, Z Z
AU  - Akarslan ZZ
AD  - Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gazi 
      University, Ankara, Turkey.
FAU - Erten, H
AU  - Erten H
AD  - Department of Operative Dentistry, Faculty of Dentistry, Gazi University, Ankara, 
      Turkey.
FAU - Coskun-Cevher, S
AU  - Coskun-Cevher S
AD  - Department of Biology, Faculty of Science and Arts, Gazi University, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Antioxidants)
RN  - 0 (Free Radicals)
RN  - 0 (Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - GAN16C9B8O (Glutathione)
RN  - Sutton disease 2
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Free Radicals/metabolism
MH  - Glutathione/*blood
MH  - Humans
MH  - Immunity, Cellular/*immunology
MH  - Interleukin-10/blood
MH  - Interleukin-12/blood
MH  - Interleukin-2/blood
MH  - Male
MH  - Malondialdehyde/*blood
MH  - Nitric Oxide/blood
MH  - Oxidative Stress/*immunology/physiology
MH  - Peroxidase/blood
MH  - Stomatitis, Aphthous/*immunology
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC4075302
EDAT- 2014/04/25 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/04/15
CRDT- 2014/04/25 06:00
PHST- 2013/11/21 00:00 [received]
PHST- 2014/01/15 00:00 [accepted]
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/04/15 00:00 [pmc-release]
AID - S0100-879X2014005043714 [pii]
AID - 10.1590/1414-431x20143714 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2014 May;47(5):355-60. doi: 10.1590/1414-431x20143714. Epub 
      2014 May 2.