PMID- 24760128
OWN - NLM
STAT- MEDLINE
DCOM- 20141107
LR  - 20220330
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Print)
IS  - 1420-682X (Linking)
VI  - 71
IP  - 18
DP  - 2014 Sep
TI  - Developmental and pathological angiogenesis in the central nervous system.
PG  - 3489-506
LID - 10.1007/s00018-014-1625-0 [doi]
AB  - Angiogenesis, the formation of new blood vessels from pre-existing vessels, in 
      the central nervous system (CNS) is seen both as a normal physiological response 
      as well as a pathological step in disease progression. Formation of the 
      blood-brain barrier (BBB) is an essential step in physiological CNS angiogenesis. 
      The BBB is regulated by a neurovascular unit (NVU) consisting of endothelial and 
      perivascular cells as well as vascular astrocytes. The NVU plays a critical role 
      in preventing entry of neurotoxic substances and regulation of blood flow in the 
      CNS. In recent years, research on numerous acquired and hereditary disorders of 
      the CNS has increasingly emphasized the role of angiogenesis in disease 
      pathophysiology. Here, we discuss molecular mechanisms of CNS angiogenesis during 
      embryogenesis as well as various pathological states including brain tumor 
      formation, ischemic stroke, arteriovenous malformations, and neurodegenerative 
      diseases.
FAU - Vallon, Mario
AU  - Vallon M
AD  - Division of Hematology, Stanford University School of Medicine, 269 Campus Drive, 
      CCSR 3100, Stanford, CA, 94305, USA, mvallon@stanford.edu.
FAU - Chang, Junlei
AU  - Chang J
FAU - Zhang, Haijing
AU  - Zhang H
FAU - Kuo, Calvin J
AU  - Kuo CJ
LA  - eng
GR  - R01 NS064517/NS/NINDS NIH HHS/United States
GR  - 1R01NS064517/NS/NINDS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140424
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Arteriovenous Malformations/pathology
MH  - Blood-Brain Barrier
MH  - Brain Neoplasms/blood supply
MH  - Central Nervous System/*blood supply
MH  - Embryonic Development
MH  - Humans
MH  - Models, Biological
MH  - *Neovascularization, Pathologic
MH  - *Neovascularization, Physiologic
MH  - Neurodegenerative Diseases/*pathology
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC4165859
MID - NIHMS589088
EDAT- 2014/04/25 06:00
MHDA- 2014/11/08 06:00
PMCR- 2015/09/01
CRDT- 2014/04/25 06:00
PHST- 2014/01/30 00:00 [received]
PHST- 2014/04/03 00:00 [accepted]
PHST- 2014/04/02 00:00 [revised]
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/11/08 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.1007/s00018-014-1625-0 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2014 Sep;71(18):3489-506. doi: 10.1007/s00018-014-1625-0. Epub 
      2014 Apr 24.