PMID- 24760137
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20140924
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 63
IP  - 10
DP  - 2014 Oct
TI  - Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with 
      type 2 diabetes.
PG  - 3523-9
LID - 10.2337/db14-0122 [doi]
AB  - Cerebral small vessel disease, including microvascular lesions, is considered to 
      play an important role in the development of type 2 diabetes mellitus 
      (T2DM)-associated cognitive deficits. With ultra-high field MRI, microvascular 
      lesions (e.g., microinfarcts and microbleeds) can now be visualized in vivo. For 
      the current study, 48 nondemented older individuals with T2DM (mean age 70.3 +/- 
      4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 
      7-Tesla brain MRI scan and a detailed cognitive assessment. The occurrence of 
      cortical microinfarcts and cerebral microbleeds was assessed on fluid-attenuated 
      inversion recovery and T1-weighted and T2*-weighted images, respectively, 
      compared between the groups, and related to cognitive performance. Microinfarcts 
      were found in 38% of control subjects and 48% of patients with T2DM. Microbleeds 
      were present in 41% of control subjects and 33% of patients (all P > 0.05). The 
      presence and number of microinfarcts or microbleeds were unrelated to cognitive 
      performance. This study showed that microvascular brain lesions on ultra-high 
      field MRI are not significantly more common in well-controlled patients with T2DM 
      than in control subjects.
CI  - (c) 2014 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Brundel, Manon
AU  - Brundel M
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, the Netherlands m.brundel-2@umcutrecht.nl.
FAU - Reijmer, Yael D
AU  - Reijmer YD
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
FAU - van Veluw, Susanne J
AU  - van Veluw SJ
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
FAU - Kuijf, Hugo J
AU  - Kuijf HJ
AD  - Image Sciences Institute, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Luijten, Peter R
AU  - Luijten PR
AD  - Department of Radiology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Kappelle, L Jaap
AU  - Kappelle LJ
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
FAU - Biessels, Geert Jan
AU  - Biessels GJ
AD  - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, the Netherlands.
CN  - Utrecht Vascular Cognitive Impairment Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*blood supply/pathology
MH  - Cerebral Small Vessel Diseases/complications/*pathology
MH  - Cognition Disorders/etiology/*pathology
MH  - Diabetes Mellitus, Type 2/complications/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Microvessels/*pathology
FIR - Biessels, G J
IR  - Biessels GJ
FIR - Bouvy, W
IR  - Bouvy W
FIR - Brundel, M
IR  - Brundel M
FIR - Heringa, S
IR  - Heringa S
FIR - Kappelle, L J
IR  - Kappelle LJ
FIR - van den Berg, E
IR  - van den Berg E
FIR - de Bresser, J
IR  - de Bresser J
FIR - Kuijf, H J
IR  - Kuijf HJ
FIR - Leemans, A
IR  - Leemans A
FIR - Luijten, P R
IR  - Luijten PR
FIR - Mali, W P Th
IR  - Mali WP
FIR - Viergever, M A
IR  - Viergever MA
FIR - Vincken, K L
IR  - Vincken KL
FIR - Zwanenburg, J
IR  - Zwanenburg J
FIR - Algra, A
IR  - Algra A
FIR - Rutten, G E H M
IR  - Rutten GE
EDAT- 2014/04/25 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - db14-0122 [pii]
AID - 10.2337/db14-0122 [doi]
PST - ppublish
SO  - Diabetes. 2014 Oct;63(10):3523-9. doi: 10.2337/db14-0122. Epub 2014 Apr 23.