PMID- 24760498
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20220317
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 20
IP  - 4
DP  - 2014 Oct
TI  - The role of protein p16(INK4a) in glottic laryngeal squamous cell carcinoma.
PG  - 909-15
LID - 10.1007/s12253-014-9773-y [doi]
AB  - Head and neck squamous cell cancer (HNSCC) includes tumors of various anatomical 
      sites sharing the common etiological factors. However some differences in 
      pathogenesis and prognosis of HNSCC have been hitherto documented. Laryngeal 
      squamous cell carcinoma (LSCC) is one the most common type of the head and neck 
      cancer. The majority of laryngeal cancers are located in the glottic area. P16 
      was recently documented to be important prognostic marker in many tumors 
      including HNSCC. The aim of our study was to assess the significance of p16 
      expression in glottic LSCC. Fifty eight patients after surgical treatment of the 
      glottic LSCC were enrolled in the retrospective study. The p16 expression was 
      immunohistochemically detected and semiquantitatively evaluated in tumor tissue. 
      The results were statistically correlated with clinical and pathological 
      parameters. Protein p16 was expressed in glottic LSCC of 15 patients (25.9 %). 
      Statistically significant higher p16 overexpression was proven in non-smokers in 
      comparison with smokers (75 % versus 18 %; p =0.003). Recurrent cancer was 
      diagnosed in 8 patients (13.8 %), and all these tumors were p16 negative. Our 
      study shows, that p16 expression in glottic LSCC especially in subgroup of 
      non-smokers might be promising prognosticator of better clinical outcome in 
      routine practice. The p16 status did not statistically correlate with cervical 
      lymph node metastases or with grading and staging of cancers, respectively. The 
      preliminary results suggest that p16 overexpression in glottic LSCC may identify 
      patients at low risk of disease recurrence. However, the pathobiology of this 
      tumor as well as predictive role of p16 expression in laryngeal cancer still 
      remains to be better elucidated.
FAU - Kalfert, David
AU  - Kalfert D
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital 
      Hradec Kralove, Prague, Czech Republic.
FAU - Celakovsky, Petr
AU  - Celakovsky P
FAU - Laco, Jan
AU  - Laco J
FAU - Ludvikova, Marie
AU  - Ludvikova M
LA  - eng
PT  - Journal Article
DEP - 20140424
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/secondary
MH  - Cyclin-Dependent Kinase Inhibitor p16/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Glottis/*metabolism/pathology
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/*metabolism/mortality/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2014/04/25 06:00
MHDA- 2015/07/08 06:00
CRDT- 2014/04/25 06:00
PHST- 2013/08/05 00:00 [received]
PHST- 2014/03/27 00:00 [accepted]
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
AID - 10.1007/s12253-014-9773-y [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2014 Oct;20(4):909-15. doi: 10.1007/s12253-014-9773-y. Epub 
      2014 Apr 24.