PMID- 24760856
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 17
DP  - 2014 Apr 23
TI  - Decoding ventromedial hypothalamic neural activity during male mouse aggression.
PG  - 5971-84
LID - 10.1523/JNEUROSCI.5109-13.2014 [doi]
AB  - The ventromedial hypothalamus, ventrolateral area (VMHvl) was identified recently 
      as a critical locus for inter-male aggression. Optogenetic stimulation of VMHvl 
      in male mice evokes attack toward conspecifics and inactivation of the region 
      inhibits natural aggression, yet very little is known about its underlying neural 
      activity. To understand its role in promoting aggression, we recorded and 
      analyzed neural activity in the VMHvl in response to a wide range of social and 
      nonsocial stimuli. Although response profiles of VMHvl neurons are complex and 
      heterogeneous, we identified a subpopulation of neurons that respond maximally 
      during investigation and attack of male conspecific mice and during investigation 
      of a source of male mouse urine. These "male responsive" neurons in the VMHvl are 
      tuned to both the inter-male distance and the animal's velocity during attack. 
      Additionally, VMHvl activity predicts several parameters of future aggressive 
      action, including the latency and duration of the next attack. Linear regression 
      analysis further demonstrates that aggression-specific parameters, such as 
      distance, movement velocity, and attack latency, can model ongoing VMHvl activity 
      fluctuation during inter-male encounters. These results represent the first 
      effort to understand the hypothalamic neural activity during social behaviors 
      using quantitative tools and suggest an important role for the VMHvl in encoding 
      movement, sensory, and motivation-related signals.
FAU - Falkner, Annegret L
AU  - Falkner AL
AD  - Department of Psychiatry, Institute of Neuroscience, New York University School 
      of Medicine, New York, New York 10016, and Division of Biology, Howard Hughes 
      Medical Institute, and Computation and Neural Systems, California Institute of 
      Technology, Pasadena, California 91125.
FAU - Dollar, Piotr
AU  - Dollar P
FAU - Perona, Pietro
AU  - Perona P
FAU - Anderson, David J
AU  - Anderson DJ
FAU - Lin, Dayu
AU  - Lin D
LA  - eng
GR  - R01 MH101377/MH/NIMH NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - 1R01MH101377-01/MH/NIMH NIH HHS/United States
GR  - R01 MH085082/MH/NIMH NIH HHS/United States
GR  - MH0750053/MH/NIMH NIH HHS/United States
GR  - MH085082/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Action Potentials/*physiology
MH  - Aggression/*physiology
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Male
MH  - Mice
MH  - Neurons/*physiology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
PMC - PMC3996217
OTO - NOTNLM
OT  - aggression
OT  - hypothalamus
OT  - motivation
OT  - physiology
EDAT- 2014/04/25 06:00
MHDA- 2014/06/10 06:00
PMCR- 2014/10/23
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2014/04/25 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2014/10/23 00:00 [pmc-release]
AID - 34/17/5971 [pii]
AID - 5109-13 [pii]
AID - 10.1523/JNEUROSCI.5109-13.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Apr 23;34(17):5971-84. doi: 10.1523/JNEUROSCI.5109-13.2014.