PMID- 24761809
OWN - NLM
STAT- MEDLINE
DCOM- 20141009
LR  - 20140721
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 166
IP  - 3
DP  - 2014 Aug
TI  - 'Double-Hit' cytogenetic status may not be predicted by baseline 
      clinicopathological characteristics and is highly associated with overall 
      survival in B cell lymphoma patients.
PG  - 369-74
LID - 10.1111/bjh.12901 [doi]
AB  - 'Double-Hit' (DH) B cell non-Hodgkin lymphomas are characterized by the presence 
      of a MYC rearrangement and additional rearrangement(s) most commonly involving 
      BCL2 and/or BCL6. Patients with DH lymphomas are unlikely to achieve long-term 
      survival when treated with standard immunochemotherapy alone. DH gene 
      rearrangements can be identified through metaphase karyotyping or more sensitive 
      fluorescence in situ hybridization (FISH), although the latter is not routinely 
      performed. We report 53 cases of B cell lymphoma that underwent diagnostic 
      metaphase karyotying or FISH for MYC rearrangements. DH lymphoma was detected in 
      17 cases. No baseline factor, including age, serum lactate dehydrogenase, stage, 
      International Prognostic Index or histology predicted for DH status. The median 
      overall survival was significantly shorter for DH compared to non-DH lymphoma 
      patients (8.2 vs. 56.8 months, P < 0.001). DH status retained the most 
      statistically significant association with overall survival on multivariate Cox 
      regression analysis. DH status could not be inferred by baseline disease- or 
      patient-related characteristics and was most predictive of overall survival in 
      this cohort of B cell lymphoma patients. These findings support the practice of 
      routine performance of FISH for DH gene rearrangements on B cell lymphoma 
      specimens in order to effectively identify DH patients who may benefit from 
      risk-adapted therapy.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Landsburg, Daniel J
AU  - Landsburg DJ
AD  - Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, 
      Philadelphia, PA, USA.
FAU - Nasta, Sunita D
AU  - Nasta SD
FAU - Svoboda, Jakub
AU  - Svoboda J
FAU - Morrissette, Jennifer J D
AU  - Morrissette JJ
FAU - Schuster, Stephen J
AU  - Schuster SJ
LA  - eng
PT  - Journal Article
DEP - 20140425
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Gene Rearrangement
MH  - Humans
MH  - Lymphoma, B-Cell/*genetics/mortality/*pathology
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Translocation, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - MYC
OT  - chemotherapy
OT  - fluorescence in situ hybridization
OT  - survival
OT  - 'Double-Hit' lymphoma
EDAT- 2014/04/26 06:00
MHDA- 2014/10/10 06:00
CRDT- 2014/04/26 06:00
PHST- 2013/12/26 00:00 [received]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2014/04/26 06:00 [entrez]
PHST- 2014/04/26 06:00 [pubmed]
PHST- 2014/10/10 06:00 [medline]
AID - 10.1111/bjh.12901 [doi]
PST - ppublish
SO  - Br J Haematol. 2014 Aug;166(3):369-74. doi: 10.1111/bjh.12901. Epub 2014 Apr 25.