PMID- 24762460
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20211021
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 28
IP  - 10
DP  - 2014 Oct
TI  - Mesenchymal stromal cells in the antimicrobial host response of hematopoietic 
      stem cell recipients with graft-versus-host disease--friends or foes?
PG  - 1941-8
LID - 10.1038/leu.2014.127 [doi]
AB  - Mesenchymal stromal cells (MSCs) are multipotent cells, which exhibit broad 
      immunosuppressive activities. Moreover, they may be administered irrespectively 
      of human leukocyte antigen (HLA) compatibility, without inducing life-threatening 
      immunological reactions, as they express no HLA class II and limited HLA class I 
      antigens under resting conditions. These characteristics have made MSC an 
      appealing candidate for cell therapy after hematopoietic stem cell 
      transplantation (HSCT), for example, for treatment of graft-versus-host disease 
      (GvHD) or for graft rejection prevention/treatment in allogeneic HSCT recipients. 
      Unfortunately, information regarding the effect of MSC infusion on the host 
      response to infectious agents is scarce, and study results on infectious 
      complications in patients receiving MSC are conflicting. The present review 
      focuses on the available data from in vitro studies and animal models regarding 
      the interaction of MSC with bacterial, viral and fungal pathogens. In a clinical 
      part, we present the current information on infectious complications in 
      allogeneic HSCT recipients who had received MSCs as prophylaxis or treatment of 
      GvHD disease.
FAU - Balan, A
AU  - Balan A
AD  - 1] Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany [2] 'Victor Babes' University of 
      Medicine and Pharmacy, Timisoara, Romania.
FAU - Lucchini, G
AU  - Lucchini G
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Schmidt, S
AU  - Schmidt S
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Schneider, A
AU  - Schneider A
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Tramsen, L
AU  - Tramsen L
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Kuci, S
AU  - Kuci S
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Meisel, R
AU  - Meisel R
AD  - Department of Pediatric Oncology, Hematology, and Clinical Immunology, 
      Heinrich-Heine University, Dusseldorf, Germany.
FAU - Bader, P
AU  - Bader P
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
FAU - Lehrnbecher, T
AU  - Lehrnbecher T
AD  - Department of Pediatric Hematology and Oncology, Children's Hospital, Johann 
      Wolfgang Goethe University, Frankfurt, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140403
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Anti-Infective Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Steroids)
SB  - IM
MH  - Animals
MH  - Anti-Infective Agents/pharmacology
MH  - Bacterial Infections/complications
MH  - Clinical Trials as Topic
MH  - Disease Models, Animal
MH  - Graft vs Host Disease/*immunology
MH  - HLA Antigens/metabolism
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Immunosuppressive Agents/pharmacology
MH  - Mesenchymal Stem Cells/*cytology
MH  - Mycoses/complications
MH  - Steroids/pharmacology
MH  - Virus Diseases/complications
EDAT- 2014/04/26 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/26 06:00
PHST- 2014/01/02 00:00 [received]
PHST- 2014/02/22 00:00 [revised]
PHST- 2014/03/21 00:00 [accepted]
PHST- 2014/04/26 06:00 [entrez]
PHST- 2014/04/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - leu2014127 [pii]
AID - 10.1038/leu.2014.127 [doi]
PST - ppublish
SO  - Leukemia. 2014 Oct;28(10):1941-8. doi: 10.1038/leu.2014.127. Epub 2014 Apr 3.