PMID- 2476293
OWN - NLM
STAT- MEDLINE
DCOM- 19891019
LR  - 20190721
IS  - 0013-4694 (Print)
IS  - 0013-4694 (Linking)
VI  - 74
IP  - 5
DP  - 1989 Sep-Oct
TI  - Mapping somatosensory evoked potentials to finger stimulation at intervals of 450 
      to 4000 msec and the issue of habituation when assessing early cognitive 
      components.
PG  - 347-58
AB  - Somatosensory evoked potentials (SEPs) to mild electric stimulation of two 
      fingers of the left hand were studied at regular interstimulus intervals (ISIs) 
      of 450, 800, 1400, 2500 and 4000 msec. Habituation was evaluated while the 
      subject was reading a novel so as to virtually ignore the finger stimuli while 
      maintaining steady vigilance levels. Brain SEPs recorded from 25 scalp electrodes 
      were assessed by scatter displays, electronic subtraction, bit-mapped potential 
      fields, and by calculating the Z estimator and dilation factor. Similar results 
      were obtained with randomly varying ISIs. The P14 farfield and cortical N20 did 
      not change with ISIs. The parietal P27-P45 decreased at ISIs of 800 and 450 msec, 
      but showed no significant habituation at ISIs of 1400, 2500 or 4000 msec. This 
      validated the control conditions used for assessing the early cognitive P30 and 
      P40 to attended target stimuli. The frontal N30 also decremented the shorter ISIs 
      but still habituated up to ISIs of 2500 msec. The clear dissociation between 
      frontal N30 and parietal P27 at the larger ISIs suggests that they involve at 
      least in part distinct neural generators.
FAU - Tomberg, C
AU  - Tomberg C
AD  - Brain Research Unit, University of Brussels, Belgium.
FAU - Desmedt, J E
AU  - Desmedt JE
FAU - Ozaki, I
AU  - Ozaki I
FAU - Nguyen, T H
AU  - Nguyen TH
FAU - Chalklin, V
AU  - Chalklin V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Electroencephalogr Clin Neurophysiol
JT  - Electroencephalography and clinical neurophysiology
JID - 0375035
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Brain Mapping
MH  - Cognition/*physiology
MH  - Electric Stimulation
MH  - *Evoked Potentials, Somatosensory
MH  - Female
MH  - Fingers/*physiology
MH  - Habituation, Psychophysiologic/*physiology
MH  - Humans
MH  - Male
MH  - Scalp/physiology
MH  - Time Factors
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1016/0168-5597(89)90002-6 [doi]
PST - ppublish
SO  - Electroencephalogr Clin Neurophysiol. 1989 Sep-Oct;74(5):347-58. doi: 
      10.1016/0168-5597(89)90002-6.