PMID- 24763406
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20151119
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 234
IP  - 2
DP  - 2014 Jun
TI  - Paraoxonase-1 activity and oxidative stress in patients with anterior ST 
      elevation myocardial infarction undergoing primary percutaneous coronary 
      intervention with and without no-reflow.
PG  - 415-20
LID - S0021-9150(14)00154-3 [pii]
LID - 10.1016/j.atherosclerosis.2014.03.005 [doi]
AB  - BACKGROUND: Reperfusion and ischemic injuries are pathogenetic mechanisms of 
      no-reflow. Oxidative stress plays a critical role during ischemia as well as 
      during the reperfusion phase following ST elevation myocardial infarction 
      (STEMI). We sought to investigate the relationship between no-reflow with 
      paraoxonase-1 (PON-1) activity and oxidative stress markers (total antioxidant 
      capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), lipid 
      hydro-peroxide (LOOH)) in patients with anterior STEMI undergoing primary 
      percutaneous coronary intervention (PCI). METHODS: In this study, 319 consecutive 
      anterior STEMI patients undergoing primary PCI were prospectively included (mean 
      age 56.5 +/- 12.5 years). The patients were divided into two groups as normal flow 
      (n = 231) and no-reflow (n = 88) groups. Serum PON-1 activity was measured 
      spectrophotometrically. TAC and TOS levels were determined by using an automated 
      measurement method. LOOH levels were measured by ferrous oxidation with xylenol 
      orange assay. RESULTS: PON-1 activity and TAC levels were significantly lower and 
      TOS, OSI and LOOH levels were significantly higher in patients with no-reflow 
      compared to normal flow group (p < 0.05, for all). On multivariate logistic 
      regression analysis, PON-1 activity (beta = 0.976, 95% CI = 0.962-0.990, p = 0.001) 
      and OSI (beta = 1.094, 95% CI = 1.042-1.148, p < 0.001) as well as diabetes, 
      infarction time, thrombus score and initial SYNTAX score were independently 
      associated with no-reflow. CONCLUSION: In patients with no-reflow compared with 
      normal flow, oxidants are increased, while serum PON-1 activity and antioxidants 
      are decreased. This result shows that increased oxidative stress has a role in 
      the pathogenesis of no-reflow.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Gur, Mustafa
AU  - Gur M
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey. Electronic address: drmugur@yahoo.com.
FAU - Turkoglu, Caner
AU  - Turkoglu C
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Taskin, Abdullah
AU  - Taskin A
AD  - Harran University, School of Medicine, Department of Clinical Biochemistry, 
      Sanliurfa, Turkey.
FAU - Ucar, Hakan
AU  - Ucar H
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Borekci, Abdurrezzak
AU  - Borekci A
AD  - Kafkas University, School of Medicine, Department of Cardiology, Kars, Turkey.
FAU - Seker, Taner
AU  - Seker T
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Gozukara, Mehmet Yavuz
AU  - Gozukara MY
AD  - Mersin State Hospital, Department of Internal Medicine, Mersin, Turkey.
FAU - Kaypakli, Onur
AU  - Kaypakli O
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Akyol, Selahattin
AU  - Akyol S
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Selek, Sahbettin
AU  - Selek S
AD  - Harran University, School of Medicine, Department of Clinical Biochemistry, 
      Sanliurfa, Turkey.
FAU - Sahin, Durmus Yildiray
AU  - Sahin DY
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Elbasan, Zafer
AU  - Elbasan Z
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
FAU - Cayli, Murat
AU  - Cayli M
AD  - Adana Numune Training and Research Hospital, Department of Cardiology, Adana, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140403
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Oxidants)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anterior Wall Myocardial Infarction/blood/diagnosis/enzymology/*therapy
MH  - Antioxidants/metabolism
MH  - Aryldialkylphosphatase/*blood
MH  - Biomarkers/blood
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - Lipid Peroxides/blood
MH  - Male
MH  - Middle Aged
MH  - No-Reflow Phenomenon/blood/*enzymology/etiology
MH  - Oxidants/blood
MH  - *Oxidative Stress
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Prospective Studies
MH  - Risk Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Antioxidant
OT  - Myocardial infarction
OT  - No-reflow
OT  - Oxidative stress
OT  - Paraoxonase
EDAT- 2014/04/26 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/04/26 06:00
PHST- 2013/08/14 00:00 [received]
PHST- 2014/03/05 00:00 [revised]
PHST- 2014/03/10 00:00 [accepted]
PHST- 2014/04/26 06:00 [entrez]
PHST- 2014/04/26 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - S0021-9150(14)00154-3 [pii]
AID - 10.1016/j.atherosclerosis.2014.03.005 [doi]
PST - ppublish
SO  - Atherosclerosis. 2014 Jun;234(2):415-20. doi: 
      10.1016/j.atherosclerosis.2014.03.005. Epub 2014 Apr 3.