PMID- 24764457
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140425
LR  - 20211021
IS  - 1476-9255 (Print)
IS  - 1476-9255 (Electronic)
IS  - 1476-9255 (Linking)
VI  - 10
DP  - 2013
TI  - Prenatal exposure to lipopolysaccharide results in myocardial remodelling in 
      adult murine offspring.
PG  - 35
LID - 10.1186/1476-9255-10-35 [doi]
AB  - BACKGROUND: The epigenetic plasticity hypothesis indicates that pregnancy 
      exposure may result in adult-onset diseases, including hypertension, diabetes and 
      cardiovascular disease, in offspring. In a previous study, we discovered that 
      prenatal exposure to inflammatory stimulants, such as lipopolysaccharides (LPS), 
      could lead to hypertension in adult rat offspring. In the present study, we 
      further demonstrate that maternal inflammation induces cardiac hypertrophy and 
      dysfunction via ectopic over-expression of nuclear transcription factor kappaB (NF- 
      kappaB), and pyrrolidine dithiocarbamate (PDTC) can protect cardiac function by 
      reducing maternal inflammation. METHODS: Pregnant SD rats were randomly divided 
      into three groups and intraperitoneally injected with a vehicle, LPS 
      (0.79 mg/kg), or LPS (0.79 mg/kg) plus PDTC (100 mg/kg) at 8 to 12 days of 
      gestation. The offspring were raised until 4 and 8 months old, at which point an 
      echocardiographic study was performed. The left ventricular (LV) mass index and 
      apoptosis were examined. RESULTS: At 4 months of age, the LPS offspring exhibited 
      augmented posterior wall thickness. These rats displayed left ventricle (LV) 
      hypertrophy and LV diastolic dysfunction as well as a higher apoptotic index, a 
      higher level of Bax and a lower level of Bcl-2 at 8 months of age. The protein 
      levels of NF-kappaB (p65) in the myocardium of the offspring were measured at this 
      time. NF-kappaB protein levels were higher in the myocardium of LPS offspring. The 
      offspring that were prenatally treated with PDTC displayed improved signs of 
      blood pressure (BP) and LV hypertrophy. CONCLUSIONS: Maternal inflammation can 
      induce cardiac hypertrophy in offspring during aging accompanied with 
      hypertension emergence and can be rescued by the maternal administration of PDTC 
      (the inhibitor of NF-kappaB).
FAU - Wei, Yanling
AU  - Wei Y
AD  - The Institute of Materia Medica and Department of Pharmaceutics, College of 
      Pharmacy, The Third Military Medical University, Chongqing, China ; Department of 
      Gastroenterology, Research Institute of Surgery, Da ping Hospital, The Third 
      Military Medical University, Chongqing, China.
FAU - Du, Wenhua
AU  - Du W
AD  - Department of Ultrasound, Research Institute of Surgery, Da ping Hospital, The 
      Third Military Medical University, Chongqing, China.
FAU - Xiong, Xiuqin
AU  - Xiong X
AD  - Department of Ultrasound, Research Institute of Surgery, Da ping Hospital, The 
      Third Military Medical University, Chongqing, China.
FAU - He, Xiaoyan
AU  - He X
AD  - The Institute of Materia Medica and Department of Pharmaceutics, College of 
      Pharmacy, The Third Military Medical University, Chongqing, China.
FAU - Ping Yi
AU  - Ping Yi
AD  - Department of Gynaecology, Research Institute of Surgery, Da ping Hospital, The 
      Third Military Medical University, Chongqing, China.
FAU - Deng, Youcai
AU  - Deng Y
AD  - The Institute of Materia Medica and Department of Pharmaceutics, College of 
      Pharmacy, The Third Military Medical University, Chongqing, China.
FAU - Chen, Dongfeng
AU  - Chen D
AD  - Department of Gastroenterology, Research Institute of Surgery, Da ping Hospital, 
      The Third Military Medical University, Chongqing, China.
FAU - Li, Xiaohui
AU  - Li X
AD  - The Institute of Materia Medica and Department of Pharmaceutics, College of 
      Pharmacy, The Third Military Medical University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20131119
PL  - England
TA  - J Inflamm (Lond)
JT  - Journal of inflammation (London, England)
JID - 101232234
PMC - PMC3874617
OTO - NOTNLM
OT  - Foetal development
OT  - Inhibitor of NF-kappaB
OT  - Maternal inflammation
OT  - Myocardial remodelling
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/11/19
CRDT- 2014/04/26 06:00
PHST- 2012/10/05 00:00 [received]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2014/04/26 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/11/19 00:00 [pmc-release]
AID - 1476-9255-10-35 [pii]
AID - 10.1186/1476-9255-10-35 [doi]
PST - epublish
SO  - J Inflamm (Lond). 2013 Nov 19;10:35. doi: 10.1186/1476-9255-10-35. eCollection 
      2013.