PMID- 24764546 OWN - NLM STAT- MEDLINE DCOM- 20151016 LR - 20180724 IS - 1472-1465 (Electronic) IS - 0007-1250 (Linking) VI - 205 IP - 1 DP - 2014 Jul TI - Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study. PG - 29-35 LID - 10.1192/bjp.bp.113.134064 [doi] AB - BACKGROUND: Early identification of patients with bipolar disorder during their first depressive episode is beneficial to the outcome of the disorder and treatment, but traditionally this has been a great challenge to clinicians. Recently, brain-derived neurotrophic factor (BDNF) has been suggested to be involved in the pathophysiology of bipolar disorder and major depressive disorder (MDD), but it is not clear whether BDNF levels can be used to predict bipolar disorder among patients in their first major depressive episode. AIMS: To explore whether BDNF levels can differentiate between MDD and bipolar disorder in the first depressive episode. METHOD: A total of 203 patients with a first major depressive episode as well as 167 healthy controls were recruited. After 3 years of bi-annual follow-up, 164 patients with a major depressive episode completed the study, and of these, 21 were identified as having bipolar disorder and 143 patients were diagnosed as having MDD. BDNF gene expression and plasma levels at baseline were compared among the bipolar disorder, MDD and healthy control groups. Logistic regression and decision tree methods were applied to determine the best model for predicting bipolar disorder at the first depressive episode. RESULTS: At baseline, patients in the bipolar disorder and MDD groups showed lower BDNF mRNA levels (P<0.001 and P = 0.02 respectively) and plasma levels (P = 0.002 and P = 0.01 respectively) compared with healthy controls. Similarly, BDNF levels in the bipolar disorder group were lower than those in the MDD group. These results showed that the best model for predicting bipolar disorder during a first depressive episode was a combination of BDNF mRNA levels with plasma BDNF levels (receiver operating characteristics (ROC) = 0.80, logistic regression; ROC = 0.84, decision tree). CONCLUSIONS: Our findings suggest that BDNF levels may serve as a potential differential diagnostic biomarker for bipolar disorder in a patient's first depressive episode. CI - Royal College of Psychiatrists. FAU - Li, Zezhi AU - Li Z AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Zhang, Chen AU - Zhang C AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Fan, Jinbo AU - Fan J AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Yuan, Chengmei AU - Yuan C AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Huang, Jia AU - Huang J AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Chen, Jun AU - Chen J AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Yi, Zhenghui AU - Yi Z AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Wang, Zuowei AU - Wang Z AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Hong, Wu AU - Hong W AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Wang, Yong AU - Wang Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Lu, Weihong AU - Lu W AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Guan, Yangtai AU - Guan Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Wu, Zhiguo AU - Wu Z AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Su, Yousong AU - Su Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Cao, Lan AU - Cao L AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Hu, Yingyan AU - Hu Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Hao, Yong AU - Hao Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Liu, Mingyuan AU - Liu M AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Yu, Shunying AU - Yu S AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Cui, Donghong AU - Cui D AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Xu, Lin AU - Xu L AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Song, Yanyan AU - Song Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente FAU - Fang, Yiru AU - Fang Y AD - Zezhi Li, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Chen Zhang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, and Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Jinbo Fan, PhD, Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, USA; Chengmei Yuan, MD, PhD, Jia Huang, MD, Jun Chen, MD, PhD, Zhenghui Yi, MD, PhD, Zuowei Wang, MD, PhD, Wu Hong, MD, PhD, Yong Wang, MD, PhD, Weihong Lu, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yangtai Guan, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Zhiguo Wu, MD, PhD, Yousong Su, MD, Lan Cao, MD, Yingyan Hu, MD, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Yong Hao, MD, PhD, Mingyuan Liu, MD, PhD, Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China; Shunying Yu, MD, PhD, Donghong Cui, MD, PhD, Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Lin Xu, PhD, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; Yanyan Song, PhD, Department of Pharmacology and Biostatistics, Institute of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China; Yiru Fang, MD, PhD, Division of Mood Disorders, Shanghai Mental Health Cente LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140424 PL - England TA - Br J Psychiatry JT - The British journal of psychiatry : the journal of mental science JID - 0342367 RN - 0 (Biomarkers) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM CIN - Br J Psychiatry. 2014 Nov;205(5):410. PMID: 25368362 CIN - Br J Psychiatry. 2014 Nov;205(5):410-1. PMID: 25368363 CIN - Br J Psychiatry. 2015 Jan;206(1):79. PMID: 25561488 CIN - Br J Psychiatry. 2015 Jan;206(1):79-80. PMID: 25561489 MH - Adult MH - Biomarkers/blood MH - Bipolar Disorder/blood/*diagnosis MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder, Major/blood/*diagnosis MH - Diagnosis, Differential MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Young Adult EDAT- 2014/04/26 06:00 MHDA- 2015/10/17 06:00 CRDT- 2014/04/26 06:00 PHST- 2014/04/26 06:00 [entrez] PHST- 2014/04/26 06:00 [pubmed] PHST- 2015/10/17 06:00 [medline] AID - S0007125000276964 [pii] AID - 10.1192/bjp.bp.113.134064 [doi] PST - ppublish SO - Br J Psychiatry. 2014 Jul;205(1):29-35. doi: 10.1192/bjp.bp.113.134064. Epub 2014 Apr 24.