PMID- 24765208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 7
IP  - 5
DP  - 2014 May
TI  - Association of interleukin-10 promoter polymorphisms and corresponding plasma 
      levels with susceptibility to laryngeal squamous cell carcinoma.
PG  - 1721-1727
AB  - Interleukin (IL)-10 is critically involved in tumorigenesis. In the present 
      study, the association between the IL-10 -1082/-819/-592 promoter polymorphisms, 
      the plasma IL-10 levels and the risk of laryngeal squamous cell carcinoma (LSCC) 
      was investigated in a prospective, case-control study. In total, 146 patients 
      with LSCC, 61 with vocal leukoplakia and 119 healthy controls were genotyped for 
      the IL-10 gene (IL-10 -1082 A/G, -819 T/C and -592 A/C) using pyrosequencing, and 
      their plasma IL-10 levels were analyzed by ELISA. The patients with LSCC had a 
      significantly higher frequency of AC at position -592 and -819 (OR, 1.82 and 
      P=0.024) compared with the control, and a higher frequency of AG at position 
      -1082 (OR, 2.20 and P=0.037). The patients with advanced LSCC had a significantly 
      higher frequency of AG+GG at position -1082 compared with those with early-stage 
      LSCC (OR, 3.13 and P=0.008 vs. OR, 2.06 and P=0.068). The patients with lymph 
      node metastasis had a significantly higher frequency of AG+GG at position -1082 
      compared with the patients with no lymph node metastasis (OR, 2.97 and P=0.048 
      vs. OR, 2.23 and P=0.035). In addition, the patients with high frequencies of 
      each genotype polymorphism had high plasma IL-10 concentrations. The present 
      study indicates that the IL-10 -1082/-819/-592 promoter polymorphisms and 
      corresponding high plasma IL-10 concentrations are associated with LSCC, and that 
      variations in genotype distribution and plasma IL-10 concentrations may be 
      associated with the stage and the lymph node metastasis status of LSCC.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Zhang, Duo
AU  - Zhang D
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Li, Qing
AU  - Li Q
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
FAU - Zhou, Lin
AU  - Zhou L
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
FAU - Liu, Fei
AU  - Liu F
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
FAU - Chou, Kuang-Yen
AU  - Chou KY
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan 
      University, Shanghai 200031, P.R. China.
FAU - Lu, Li-Ming
AU  - Lu LM
AD  - Shanghai Institute of Immunology, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200025, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140226
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3997667
OTO - NOTNLM
OT  - cytokines
OT  - interleukin-10
OT  - laryngeal squamous cell carcinoma
OT  - polymorphism
OT  - vocal leukoplakia
EDAT- 2014/04/26 06:00
MHDA- 2014/04/26 06:01
PMCR- 2014/02/26
CRDT- 2014/04/26 06:00
PHST- 2013/07/31 00:00 [received]
PHST- 2014/02/07 00:00 [accepted]
PHST- 2014/04/26 06:00 [entrez]
PHST- 2014/04/26 06:00 [pubmed]
PHST- 2014/04/26 06:01 [medline]
PHST- 2014/02/26 00:00 [pmc-release]
AID - ol-07-05-1721 [pii]
AID - 10.3892/ol.2014.1914 [doi]
PST - ppublish
SO  - Oncol Lett. 2014 May;7(5):1721-1727. doi: 10.3892/ol.2014.1914. Epub 2014 Feb 26.