PMID- 24767008
OWN - NLM
STAT- MEDLINE
DCOM- 20141121
LR  - 20220310
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 162
DP  - 2014 Jun
TI  - Serum level of brain derived neurotrophic factor (BDNF) among patients with 
      bipolar disorder.
PG  - 67-72
LID - S0165-0327(14)00086-X [pii]
LID - 10.1016/j.jad.2014.02.038 [doi]
AB  - BACKGROUND: There is a growing body of evidence that serum brain derived 
      neurotrophic factor (BDNF) is altered during the episodes of bipolar disorder. 
      The aim of this study was to investigate serum BDNF levels in bipolar disorder 
      patients during manic and depressive episodes and its clinical utility in bipolar 
      disorder compared to other psychiatric disorders. METHODS: The study was 
      conducted on 80 Egyptian patients, who were classified into 4 groups: group Ia 
      (25 patients with depressive episodes), group Ib (25 patients with manic 
      episodes), group II (15 patients having Schizophrenia) as pathological controls 
      and group III (15 healthy subjects) as controls. All subjects were diagnosed 
      according to DSM-IV, assessed using the Hamilton Rating Scale for depression 
      (HAM-D), and the Young Mania Rating Scale (YMRS). sBDNF concentrations were 
      measured using the quantitative sandwich enzyme immunoassay technique. RESULTS: 
      sBDNF showed significantly lower levels in patients with depressive episodes or 
      manic episodes. The best cut-off for sBDNF in discriminating depressed patient 
      from healthy control was </=33,000pg/ml (AUC=0.891, sensitivity of 84%, and 
      specificity of 80%). Moreover, the best cut-off for sBDNF in discriminating mania 
      patients׳ group from healthy control was </=29,500pg/ml, (AUC=0.984, asensitivity 
      of 96%, and specificity of 86.7%). LIMITATIONS: Only a small sample size was 
      considered which included only drug free patients. BDNF was measured in serum not 
      in CSF or brain tissue. CONCLUSIONS: Low sBDNF levels are strongly associated 
      with active phases of bipolar disorder, in depressive and manic episodes.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Rabie, Menan A
AU  - Rabie MA
AD  - Institute of Psychiatry, Ain Shams University, PO Box 11657, Cairo, Egypt. 
      Electronic address: menan74@yahoo.com.
FAU - Mohsen, Manal
AU  - Mohsen M
AD  - Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, 
      Cairo, Egypt.
FAU - Ibrahim, Mona
AU  - Ibrahim M
AD  - Institute of Psychiatry, Ain Shams University, PO Box 11657, Cairo, Egypt.
FAU - El-Sawy Mahmoud, Rania
AU  - El-Sawy Mahmoud R
AD  - Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, 
      Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20140324
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Bipolar Disorder/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Egypt
MH  - Female
MH  - Humans
MH  - Limit of Detection
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Bipolar
EDAT- 2014/04/29 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/04/29 06:00
PHST- 2014/02/03 00:00 [received]
PHST- 2014/02/28 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0165-0327(14)00086-X [pii]
AID - 10.1016/j.jad.2014.02.038 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Jun;162:67-72. doi: 10.1016/j.jad.2014.02.038. Epub 2014 
      Mar 24.