PMID- 24767374
OWN - NLM
STAT- MEDLINE
DCOM- 20150221
LR  - 20140428
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 46
IP  - 3
DP  - 2014 Apr
TI  - Elevation of C-reactive protein level and its correlation with psychiatric 
      comorbidities in recipients after liver transplantation.
PG  - 894-6
LID - S0041-1345(13)01426-7 [pii]
LID - 10.1016/j.transproceed.2013.12.030 [doi]
AB  - Orthotopic liver transplantation (OLT) is the gold standard procedure for 
      treating end-stage liver disease resulting from a variety of causes. Psychiatric 
      comorbidities are common problems among patients who have undergone OLT; however, 
      the association between psychiatric comorbidity and biological factors in OLT has 
      not been investigated. In our previous study, we found a positive correlation 
      between serum C-reactive protein (CRP) level after OLT and the prevalence of 
      psychiatric comorbidities in recipients. In this retrospective cohort analysis, 
      we enrolled 279 recipients who underwent OLT during a 3-year period (from 2008 to 
      2011) at a single center. Our retrospective study showed that the recipients with 
      a higher serum CRP level at 1 month after OLT had higher psychiatric 
      comorbidities compared with the recipients with a normal serum CRP level. 
      Additionally, an in vitro study demonstrated that the down-regulation of 
      brain-derived neurotrophic factor (BDNF) gene expression by CRP treatment in 
      retinoic acid (RA) differentiated SH-SY5Y neuroblastoma cells. These clinical and 
      experimental results indicated that the overexpression of CRP may induce 
      psychiatric comorbidities through suppressed expression of the BDNF, suggesting 
      that OLT recipients who developed psychiatric comorbidities might be accompanied 
      by an immunological or acute-phase protein response. In conclusion, an activation 
      of systemic inflammatory processes may be one of the predictable signatures for 
      psychiatric comorbidities in OLT recipients.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Chen, C C
AU  - Chen CC
AD  - Center for Translational Research in Biomedical Sciences, Liver Transplantation 
      Program, Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and 
      Chang Gung University College of Medicine, Kaohsiung, Taiwan; Graduate Institute 
      of Clinical Medical Sciences, Chang Gung University College of Medicine, 
      Kaohsiung, Taiwan.
FAU - Hsu, L W
AU  - Hsu LW
AD  - Center for Translational Research in Biomedical Sciences, Liver Transplantation 
      Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
FAU - Nakano, T
AU  - Nakano T
AD  - Graduate Institute of Clinical Medical Sciences, Chang Gung University College of 
      Medicine, Kaohsiung, Taiwan.
FAU - Goto, S
AU  - Goto S
AD  - Center for Translational Research in Biomedical Sciences, Liver Transplantation 
      Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: 
      s-goto@athena.ocn.ne.jp.
FAU - Chen, C L
AU  - Chen CL
AD  - Center for Translational Research in Biomedical Sciences, Liver Transplantation 
      Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang 
      Gung University College of Medicine, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - C-Reactive Protein/*metabolism
MH  - Cell Line, Tumor
MH  - Female
MH  - Humans
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - Mental Disorders/*etiology
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2014/04/29 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/04/29 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2013/11/30 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - S0041-1345(13)01426-7 [pii]
AID - 10.1016/j.transproceed.2013.12.030 [doi]
PST - ppublish
SO  - Transplant Proc. 2014 Apr;46(3):894-6. doi: 10.1016/j.transproceed.2013.12.030.