PMID- 24768143
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20140815
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 191
IP  - 1
DP  - 2014 Sep
TI  - Impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass on the 
      hypoglycemic effect and glucagon-like peptide-1 in rats with type 2 diabetes 
      mellitus.
PG  - 123-9
LID - S0022-4804(14)00342-4 [pii]
LID - 10.1016/j.jss.2014.03.062 [doi]
AB  - BACKGROUND: The impact of the hepatic branch of the vagus and Roux-en-Y gastric 
      bypass (RYGB) on the hypoglycemic effect and glucagon-like peptide-1 (GLP-1) in 
      rats with type 2 diabetes mellitus (T2DM) was investigated, and interactions were 
      preliminarily analyzed. METHODS: A total of 45 rats with T2DM were divided into 
      four groups: sham operation (S, n = 10), sham operation with the hepatic branch 
      of the vagus resected (SV, n = 11), RYGB (n = 12), and RYGB without preservation 
      of the vagus (RYGBV, n = 12). Body mass, fasting blood glucose (FBG), fasting 
      serum insulin, and concentrations of fasting serum GLP-1 were examined in the 
      first, second, fourth, and eighth week before and after surgery. The effects of 
      RYGB and the hepatic branch of the vagus on GLP-1 levels in the eighth 
      postoperative week were also analyzed. RESULTS: RYGB caused a significant 
      reduction in the weight of rats with T2DM (P < 0.05), improved the levels of 
      serum GLP-1 and insulin (P < 0.05), and decreased FBG level (P < 0.05). Retention 
      of the hepatic branch of the vagus maintained weight reduction for a longer 
      period (P < 0.05) and increased the levels of serum GLP-1 and insulin (P < 0.05), 
      but had no impact on FBG level (P > 0.05). CONCLUSIONS: RYGB had better 
      therapeutic efficacy in rats with T2DM. Care should be taken during RYGB surgery 
      to preserve the hepatic branch of the vagus.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Qiu, Nian-Cun
AU  - Qiu NC
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China.
FAU - Song, Xin
AU  - Song X
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China.
FAU - Liu, Miao-E
AU  - Liu ME
AD  - Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine 
      Zhejiang University, Zhejiang 310000, China.
FAU - Li, Xiao-Ke
AU  - Li XK
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China.
FAU - Shan, Cheng-Xiang
AU  - Shan CX
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China. Electronic address: 
      chengxiangshan@hotmail.com.
FAU - Qiu, Ming
AU  - Qiu M
AD  - Department of General Surgery, Changzheng Hospital, Second Military Medical 
      University, Shanghai 200003, China. Electronic address: qium127@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140326
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/metabolism/surgery
MH  - Diabetes Mellitus, Type 2/metabolism/*surgery
MH  - Disease Models, Animal
MH  - Gastric Bypass/*methods
MH  - Glucagon-Like Peptide 1/*blood
MH  - Hypoglycemia/metabolism
MH  - Insulin/blood
MH  - Liver/*innervation
MH  - Male
MH  - Obesity/metabolism/surgery
MH  - Postoperative Period
MH  - Rats, Sprague-Dawley
MH  - Vagotomy/*adverse effects
MH  - Vagus Nerve/anatomy & histology/physiology/*surgery
MH  - Weight Loss/physiology
OTO - NOTNLM
OT  - Glucagon-like peptide-1
OT  - Hepatic branch of the vagus
OT  - Obesity
OT  - Roux-en-Y gastric bypass
OT  - Type 2 diabetes
EDAT- 2014/04/29 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/04/29 06:00
PHST- 2014/01/20 00:00 [received]
PHST- 2014/03/15 00:00 [revised]
PHST- 2014/03/21 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0022-4804(14)00342-4 [pii]
AID - 10.1016/j.jss.2014.03.062 [doi]
PST - ppublish
SO  - J Surg Res. 2014 Sep;191(1):123-9. doi: 10.1016/j.jss.2014.03.062. Epub 2014 Mar 
      26.