PMID- 24768314
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20211021
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 341
IP  - 1-2
DP  - 2014 Jun 15
TI  - Tractography reveals diffuse white matter abnormalities in Myotonic Dystrophy 
      Type 1.
PG  - 73-8
LID - S0022-510X(14)00226-3 [pii]
LID - 10.1016/j.jns.2014.04.005 [doi]
AB  - Cerebral involvement in Myotonic Dystrophy Type 1 (DM1) is well-established but 
      not well characterized. This study applied new Diffusion Tensor Imaging (DTI) 
      tractography to characterize white matter disturbance in adults with DM1. 
      Forty-five participants with DM1 and 44 control participants had MRIs on a 
      Siemens 3T TIM Trio scanner. Data were processed with TRActs Constrained by 
      UnderLying Anatomy (TRACULA) and 7 tracts were evaluated. Bilateral disturbances 
      in white matter integrity were seen in all tracts in participants with DM1 
      compared to controls. There were no right-left hemisphere differences. The 
      resulting DTI metrics were correlated with cognitive functioning, particularly 
      working memory and processing speed. Motor speed was not significantly correlated 
      with white matter microstructural integrity and, thus, was not the core 
      explanation for the working memory and processing speed findings. White matter 
      integrity was correlated with important clinical variables including the muscular 
      impairment rating scale (MIRS). CTG repeat length was moderately associated with 
      white matter status in corticospinal tract and cingulum. Sleepiness (Epworth 
      Sleepiness Scale) was moderately associated with white matter status in the 
      superior longitudinal fasciculus and cingulum. Overall, the results add to an 
      emerging literature showing widespread white matter disturbances in both 
      early-onset and adult-onset DM1. Results suggest that further investigation of 
      white matter pathology is warranted in DM1 and that non-invasive measures such as 
      DTI have a potentially important clinical value in characterizing the status of 
      individuals with DM1.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Wozniak, Jeffrey R
AU  - Wozniak JR
AD  - Department of Psychiatry, University of Minnesota-Twin Cities, F256/2B West, 2450 
      Riverside Ave., Minneapolis, MN 55454, United States. Electronic address: 
      jwozniak@umn.edu.
FAU - Mueller, Bryon A
AU  - Mueller BA
AD  - Department of Psychiatry, University of Minnesota-Twin Cities, F256/2B West, 2450 
      Riverside Ave., Minneapolis, MN 55454, United States.
FAU - Lim, Kelvin O
AU  - Lim KO
AD  - Department of Psychiatry, University of Minnesota-Twin Cities, F256/2B West, 2450 
      Riverside Ave., Minneapolis, MN 55454, United States.
FAU - Hemmy, Laura S
AU  - Hemmy LS
AD  - Department of Psychiatry, University of Minnesota-Twin Cities, F256/2B West, 2450 
      Riverside Ave., Minneapolis, MN 55454, United States.
FAU - Day, John W
AU  - Day JW
AD  - Department of Neurology, Stanford University, 300 Pasteur Drive, Room A301, MC 
      5325, Stanford, CA 94305, United States.
LA  - eng
GR  - P41 EB015894/EB/NIBIB NIH HHS/United States
GR  - P41 RR008079/RR/NCRR NIH HHS/United States
GR  - R01 NS056592/NS/NINDS NIH HHS/United States
GR  - P30 NS076408/NS/NINDS NIH HHS/United States
GR  - P30 NS057091/NS/NINDS NIH HHS/United States
GR  - P01 NS058901/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20140413
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Adult
MH  - *Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Leukoencephalopathies/*diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Myotonic Dystrophy/*complications
MH  - Neuropsychological Tests
PMC - PMC4042407
MID - NIHMS585635
OTO - NOTNLM
OT  - Brain
OT  - Diffusion Tensor Imaging
OT  - MRI
OT  - Myotonic Dystrophy
OT  - Neuropsychology
OT  - White matter
EDAT- 2014/04/29 06:00
MHDA- 2014/12/31 06:00
PMCR- 2015/06/15
CRDT- 2014/04/29 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/04/03 00:00 [revised]
PHST- 2014/04/05 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
PHST- 2015/06/15 00:00 [pmc-release]
AID - S0022-510X(14)00226-3 [pii]
AID - 10.1016/j.jns.2014.04.005 [doi]
PST - ppublish
SO  - J Neurol Sci. 2014 Jun 15;341(1-2):73-8. doi: 10.1016/j.jns.2014.04.005. Epub 
      2014 Apr 13.