PMID- 24768643
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20140513
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 268
DP  - 2014 Jul 15
TI  - Mice over-expressing BDNF in forebrain neurons develop an altered behavioral 
      phenotype with age.
PG  - 222-8
LID - S0166-4328(14)00243-5 [pii]
LID - 10.1016/j.bbr.2014.04.025 [doi]
AB  - Evidence from clinical studies suggests that abnormal activity of brain derived 
      neurotrophic factor (BDNF) contributes to the pathogenesis of autism spectrum 
      disorders (ASDs). A genetically modified line of mice over-expressing a BDNF 
      transgene in forebrain neurons was used to investigate if this mutation leads to 
      changes in behavior consistent with ASD. The mice used in these experiments were 
      behaviorally tested past 5 months of age when spontaneous seizures were evident. 
      These seizures were not observed in age-matched wildtype (WT) mice or younger 
      mice from this transgenic line. The BDNF mice in these experiments weighed less 
      than their WT littermates. The BDNF transgenic (BDNF-tg) mice demonstrated 
      similar levels of sociability in the social approach test. Conversely, the 
      BDNF-tg mice demonstrated less obsessive compulsive-like behavior in the marble 
      burying test, less anxiety-like behavior in the elevated plus maze test, and less 
      depressive-like behavior in the forced swim test. Changes in behavior were found 
      in these older mice that have not been observed in younger mice from this 
      transgenic line, which may be due to the development of seizures as the mice age. 
      These mice do not have an ASD phenotype but may be useful to study adult onset 
      epilepsy.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Weidner, Kate L
AU  - Weidner KL
AD  - City University of New York, College of Staten Island, Staten Island, NY 10314, 
      USA; New York State Institute for Basic Research in Developmental Disabilities, 
      Staten Island, NY 10314, USA. Electronic address: klw7fu@virginia.edu.
FAU - Buenaventura, Diego F
AU  - Buenaventura DF
AD  - City University of New York, College of Staten Island, Staten Island, NY 10314, 
      USA; New York State Institute for Basic Research in Developmental Disabilities, 
      Staten Island, NY 10314, USA.
FAU - Chadman, Kathryn K
AU  - Chadman KK
AD  - New York State Institute for Basic Research in Developmental Disabilities, Staten 
      Island, NY 10314, USA. Electronic address: kathryn.chadman@opwdd.ny.gov.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140422
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/*physiology/psychology
MH  - Animals
MH  - Anxiety/physiopathology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Child Development Disorders, Pervasive
MH  - Compulsive Behavior/physiopathology
MH  - Depression/physiopathology
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurons/*physiology
MH  - Neuropsychological Tests
MH  - Phenotype
MH  - Prosencephalon/growth & development/*physiology
MH  - Seizures/physiopathology
MH  - Social Behavior
OTO - NOTNLM
OT  - Autism
OT  - Behavioral phenotype
OT  - Brain derived neurotrophic factor
OT  - Social approach
OT  - Transgenic mice
EDAT- 2014/04/29 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/04/29 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2014/04/08 00:00 [revised]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0166-4328(14)00243-5 [pii]
AID - 10.1016/j.bbr.2014.04.025 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Jul 15;268:222-8. doi: 10.1016/j.bbr.2014.04.025. Epub 2014 
      Apr 22.