PMID- 24768903
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20140529
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 56
DP  - 2014 Jun
TI  - Alarin-induced antidepressant-like effects and their relationship with 
      hypothalamus-pituitary-adrenal axis activity and brain derived neurotrophic 
      factor levels in mice.
PG  - 163-72
LID - S0196-9781(14)00125-9 [pii]
LID - 10.1016/j.peptides.2014.04.009 [doi]
AB  - Alarin is a newly identified member of the galanin family of peptides. Galanin 
      has been shown to exert regulatory effects on depression. Similar to galanin in 
      distribution, alarin is also expressed in the medial amygdala and hypothalamus, 
      i.e., regions interrelated with depression. However, it remains a puzzle whether 
      alarin is involved in depression. Accordingly, we established the depression-like 
      mouse model using behavioral tests to ascertain the possible involvement of 
      alarin, with fluoxetine as a positive control. With the positive 
      antidepressant-like effects of alarin, we further examined its relationship to 
      HPA axis activity and brain-derived neurotrophic factor (BDNF) levels in 
      different brain areas in a chronic unpredictable mild stress (CUMS) paradigm. In 
      the acute studies, alarin produced a dose-related reduction in the immobility 
      duration in tail suspension test (TST) in mice. In the open-field test, 
      intracerebroventricular (i.c.v.) injection of alarin (1.0 nmol) did not impair 
      locomotion or motor coordination in the treated mice. In the CUMS paradigm, 
      alarin administration (1.0 nmol, i.c.v.) significantly improved murine behaviors 
      (FST and locomotor activity), which was associated with a decrease in 
      corticotropin-releasing hormone (CRH) mRNA levels in the hypothalamus, as well as 
      a decline in serum levels of CRH, adrenocorticotropic hormone (ACTH) and 
      corticosterone (CORT), all of which are key hormones of the HPA axis. 
      Furthermore, alarin upregulated BDNF mRNA levels in the prefrontal cortex and 
      hippocampus. These findings suggest that alarin may potentiate the development of 
      new antidepressants, which would be further secured with the identification of 
      its receptor(s).
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Wang, Ming
AU  - Wang M
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Li, Mei
AU  - Li M
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Ma, Tengfei
AU  - Ma T
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Wang, Yun
AU  - Wang Y
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China.
FAU - Gu, Shuling
AU  - Gu S
AD  - Department of Pharmacology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, 
      China. Electronic address: gushling@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140423
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Galanin-Like Peptide)
RN  - 0 (alarin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Corticotropin-Releasing Hormone/blood
MH  - Galanin-Like Peptide/*pharmacology
MH  - Hypothalamo-Hypophyseal System/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pituitary-Adrenal System/*metabolism
OTO - NOTNLM
OT  - Alarin
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Hypothalamic-pituitary-adrenal axis
EDAT- 2014/04/29 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/04/29 06:00
PHST- 2014/03/06 00:00 [received]
PHST- 2014/04/11 00:00 [revised]
PHST- 2014/04/11 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - S0196-9781(14)00125-9 [pii]
AID - 10.1016/j.peptides.2014.04.009 [doi]
PST - ppublish
SO  - Peptides. 2014 Jun;56:163-72. doi: 10.1016/j.peptides.2014.04.009. Epub 2014 Apr 
      23.