PMID- 24769004
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20211203
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 68
DP  - 2014 Aug
TI  - Maternal sleep deprivation inhibits hippocampal neurogenesis associated with 
      inflammatory response in young offspring rats.
PG  - 57-65
LID - S0969-9961(14)00097-7 [pii]
LID - 10.1016/j.nbd.2014.04.008 [doi]
AB  - Although sleep complaints are very common among pregnant women, the potential 
      adverse effects of sleep disturbance on the offspring are not well studied. 
      Growing evidence suggests that maternal stress can induce an inflammatory 
      environment on the fetal development. But people are not sure about the 
      consequences of prenatal stress such as the inflammatory responses induced by 
      maternal sleep deprivation (MSD). In the present study, we investigated the 
      effects of MSD on long-term behavioral and cognitive consequences in offspring 
      and its underlying inflammatory response pathway. The pregnant Wistar rats 
      received prolonged sleep deprivation (72h) on gestational day (GD) 4, 9, and 18, 
      respectively. The post-natal day (PND) 21 offspring showed impaired 
      hippocampus-dependent spatial learning and memory in the Morris Water Maze task 
      and anhedonia in sucrose preference experiment. Quantification of BrdU(+) and 
      DCX(+) cells revealed a significant decrease in hippocampus neurogenesis in 
      prepuberty offspring, especially for the late MSD (GD 18) group. Real-time RT-PCR 
      showed that after MSD, the expression of pro-inflammatory cytokines (IL-1beta, IL-6 
      and TNFalpha) increased in the hippocampus of offspring on PND 1, 7, 14 and 21, 
      whereas anti-inflammatory cytokine IL-10 reduced at the same time. 
      Immunofluorescence found that the cells of activated microglia were higher in the 
      brains of MSD offspring. Taken together, these results suggested that the 
      MSD-induced inflammatory response is an important factor for neurogenesis 
      impairment and neurobehavioral outcomes in prepuberty offspring.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Zhao, Qiuying
AU  - Zhao Q
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China.
FAU - Peng, Cheng
AU  - Peng C
AD  - State Key Laboratory Breeding Base of Systematic Research, Development and 
      Utilization of Chinese Medicine Resources, Pharmacy College, Chengdu University 
      of Traditional Chinese Medicine, Chengdu 610075, China.
FAU - Wu, Xiaohui
AU  - Wu X
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China.
FAU - Chen, Yubo
AU  - Chen Y
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China.
FAU - Wang, Cheng
AU  - Wang C
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China.
FAU - You, Zili
AU  - You Z
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China. Electronic address: 
      youzili@uestc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140424
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 130068-27-8 (Interleukin-10)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Body Weight/physiology
MH  - Cognition Disorders/etiology/pathology
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Female
MH  - Food Preferences/physiology
MH  - Gestational Age
MH  - Hippocampus/*physiopathology
MH  - Interleukin-10/*metabolism
MH  - Male
MH  - Maze Learning/physiology
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurogenesis/*physiology
MH  - Neuropeptides/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Ratio
MH  - Sleep Deprivation/*complications
MH  - Sucrose/administration & dosage
OTO - NOTNLM
OT  - Inflammatory response
OT  - Microglial activation
OT  - Neurogenesis
OT  - Offspring
OT  - Pregnancy
OT  - Sleep deprivation
EDAT- 2014/04/29 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/04/29 06:00
PHST- 2013/10/31 00:00 [received]
PHST- 2014/04/08 00:00 [revised]
PHST- 2014/04/14 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S0969-9961(14)00097-7 [pii]
AID - 10.1016/j.nbd.2014.04.008 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2014 Aug;68:57-65. doi: 10.1016/j.nbd.2014.04.008. Epub 2014 Apr 
      24.