PMID- 24769782
OWN - NLM
STAT- MEDLINE
DCOM- 20140527
LR  - 20140428
IS  - 2154-8331 (Print)
IS  - 2154-8331 (Linking)
VI  - 42
IP  - 2
DP  - 2014 Apr
TI  - Effect of continuous positive airway pressure on type 2 diabetes mellitus and 
      glucose metabolism.
PG  - 31-7
LID - 10.3810/hp.2014.04.1101 [doi]
AB  - BACKGROUND: Obstructive sleep apnea (OSA) is a prevalent condition that is 
      associated with significant comorbidities, including obesity, hypertension, 
      cardiovascular disease, and insulin resistance. Continuous positive airway 
      pressure (CPAP) is an effective treatment for OSA. The effect of CPAP on glucose 
      metabolism in patients with OSA has been controversial. This study evaluates the 
      impact of CPAP on patients with OSA and type 2 diabetes mellitus (T2DM) or 
      prediabetes. MATERIALS AND METHODS: PubMed, Ovid Medline, and EMBASE were 
      searched for original English language studies performed on or after 2003. 
      Subjects were aged > 18 years, were diagnosed with OSA via polysomnography, and 
      had either T2DM or prediabetes according to laboratory evaluation. RESULTS: Of 
      the 22 articles that met the selection criteria, 17 studies (77%) showed that a 
      prolonged use of CPAP produced significant changes in glucose metabolism of 
      patients who had T2DM and prediabetes. These changes were observed in studies 
      measuring glycosylated hemoglobin (HbA1c), postprandial or nocturnal glucose, and 
      insulin sensitivity or resistance. Of the 17 studies, 4 showed improvement in 
      HbA1c levels or increased insulin sensitivity only after long-term use of CPAP 
      for >/= 3 months. CONCLUSION: This literature review shows that CPAP improves not 
      only hypoxia while restoring normal breathing during sleep, but also glucose 
      metabolism in patients with OSA and T2DM or prediabetes. A few studies have shown 
      that patients can experience even better results with long-term CPAP treatment (>/= 
      3 months of daily use) for > 4 hours a night. Therefore, this improvement in 
      glucose metabolism with the use of CPAP may contribute to T2DM prevention and 
      decrease further progression of the disease. However, additional studies are 
      needed to confirm these findings.
FAU - Gallegos, Lucy
AU  - Gallegos L
AD  - Drexel University College of Medicine/Hahnemann Hospital, Department of Family 
      Medicine, Philadelphia, PA.
FAU - Dharia, Tejal
AU  - Dharia T
FAU - Gadegbeku, Annette B
AU  - Gadegbeku AB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Hosp Pract (1995)
JT  - Hospital practice (1995)
JID - 101268948
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose
MH  - Continuous Positive Airway Pressure/*methods
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology/*metabolism
MH  - Glucose/*metabolism
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Polysomnography
MH  - Prediabetic State/epidemiology/metabolism
MH  - Sleep Apnea, Obstructive/*epidemiology/*therapy
EDAT- 2014/04/29 06:00
MHDA- 2014/05/28 06:00
CRDT- 2014/04/29 06:00
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/05/28 06:00 [medline]
AID - 10.3810/hp.2014.04.1101 [doi]
PST - ppublish
SO  - Hosp Pract (1995). 2014 Apr;42(2):31-7. doi: 10.3810/hp.2014.04.1101.