PMID- 24770573 OWN - NLM STAT- MEDLINE DCOM- 20150713 LR - 20140428 IS - 2038-2502 (Electronic) IS - 0035-6484 (Linking) VI - 49 IP - 2 DP - 2014 Mar-Apr TI - Cognitive functioning and insight in schizophrenia and in schizoaffective disorder. PG - 77-83 LID - 10.1708/1461.16143 [doi] AB - AIM: The aim of this study was to investigate cognitive functioning and insight of illness in two groups of patients during their stable phases, one with schizophrenia and one with schizoaffective disorder. METHODS: We recruited 104 consecutive outpatients, 64 with schizophrenia, 40 with schizoaffective disorder, in the period between July 2010 and July 2011. They all fulfilled formal Diagnostic and Statistical Manual of Mental disorders (DSM-IV-TR) diagnostic criteria for schizophrenia and schizoaffective disorder. Psychiatric assessment included the Clinical Global Impression Scale-Severity (CGI-S), the Positive and Negative Sindrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Global Assessment of Functioning (GAF). Insight of illness was evaluated using SUMD. Neuropsychological assessment included Winsconsin Card Sorting Test (WCST), California Verbal Learning Test (CVLT), Stroop Test and Trail Making Test (TMT). Differences between the groups were tested using Chi-square test for categorical variables and one-way analysis of variance (ANOVA) for continuous variables. All variables significantly different between the two groups of subjects were subsequently analysed using a logistic regression with a backward stepwise procedure using diagnosis (schizophrenia/schizoaffective disorder) as dependent variable. RESULTS: After backward selection of variables, four variables predicted a schizoaffective disorder diagnosis: marital status, a higher number of admission, better attentive functions and awareness of specific signs or symptoms of disease. The prediction model accounted for 55% of the variance of schizoaffective disorder diagnosis. DISCUSSION: With replication, our findings would allow higher diagnostic accuracy and have an impact on clinical decision making, in light of an amelioration of vocational functioning. FAU - Birindelli, Nadia AU - Birindelli N FAU - Montemagni, Cristiana AU - Montemagni C FAU - Crivelli, Barbara AU - Crivelli B FAU - Bava, Irene AU - Bava I FAU - Mancini, Irene AU - Mancini I FAU - Rocca, Paola AU - Rocca P LA - eng PT - Journal Article PL - Italy TA - Riv Psichiatr JT - Rivista di psichiatria JID - 0425672 SB - IM MH - Adult MH - *Cognition MH - Cognition Disorders/*etiology MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Psychotic Disorders/*complications/*psychology MH - Schizophrenia/*complications MH - *Schizophrenic Psychology EDAT- 2014/04/29 06:00 MHDA- 2015/07/15 06:00 CRDT- 2014/04/29 06:00 PHST- 2014/04/29 06:00 [entrez] PHST- 2014/04/29 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - 10.1708/1461.16143 [doi] PST - ppublish SO - Riv Psichiatr. 2014 Mar-Apr;49(2):77-83. doi: 10.1708/1461.16143.