PMID- 24771286
OWN - NLM
STAT- MEDLINE
DCOM- 20150204
LR  - 20211021
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 118
IP  - 2
DP  - 2014 Jun
TI  - Recommendations for the radiological diagnosis and follow-up of neuropathological 
      abnormalities associated with tuberous sclerosis complex.
PG  - 205-223
LID - 10.1007/s11060-014-1429-y [doi]
AB  - Tuberous sclerosis complex (TSC) is a genetic condition with multisystem 
      involvement, characterized by the development of tumors and other abnormalities 
      in organs such as the brain, retina, skin, heart, kidneys, and lungs. Most 
      patients have neuropathological abnormalities such as cortical tubers, white 
      matter radial migration lines, subependymal nodules, and subependymal giant cell 
      astrocytomas (SEGAs). These lesions are associated with different neurological 
      manifestations that are frequently associated with TSC. These manifestations 
      consist of epilepsy, intellectual disability, and neurobehavioral and psychiatric 
      problems, including autism spectrum disorder. Hydrocephalus may also develop in 
      patients with SEGAs due to ventricular obstruction, when this usually 
      slow-growing tumor reaches sufficient size. Surgery has been the classical 
      approach to treat SEGAs, although this treatment is associated with substantial 
      morbidity and does not completely prevent tumor recurrence. Recently, the 
      mammalian target of rapamycin (mTOR) inhibitor, everolimus, has been approved by 
      the Food and Drug Administration and the European Medicines Agency for the 
      treatment of patients with SEGAs associated with TSC. However, the treatment of 
      SEGAs with these agents requires the development of guidelines that establish a 
      differential diagnosis between SENs and SEGAs, in which neuroradiological 
      examinations play an essential role. With the aim of improving the 
      neuroradiological diagnosis and follow-up of the neuropathological abnormalities 
      associated with TSC, a group of experts in this field has reviewed different 
      aspects related to these issues and put together, a series of statements and 
      recommendations intended to provide guidance to specialists involved in the 
      management of TSC.
FAU - Rovira, Alex
AU  - Rovira A
AD  - Neuroradiology Unit (IDI), Hospital Universitari Vall d'Hebron, Passeig de la 
      Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
FAU - Ruiz-Falco, Maria Luz
AU  - Ruiz-Falco ML
AD  - Neuropediatrics Department, Hospital Infantil Universitario Nino Jesus, Avenida 
      de Menendez Pelayo, 65, 28009, Madrid, Spain. mariluz@ruiz-falco.es.
FAU - Garcia-Esparza, Elena
AU  - Garcia-Esparza E
AD  - Neuroradiology Department, Hospital Infantil Universitario Nino Jesus, Avenida de 
      Menendez Pelayo, 65, 28009, Madrid, Spain.
FAU - Lopez-Laso, Eduardo
AU  - Lopez-Laso E
AD  - Neuropediatrics Department, Hospital Universitario Reina Sofia, Avenida Menendez 
      Pidal, s/n, 14004, Cordoba, Spain.
FAU - Macaya, Alfons
AU  - Macaya A
AD  - Neuropediatrics Department, Hospital Universitari Vall D'Hebron, Passeig de la 
      Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
FAU - Malaga, Ignacio
AU  - Malaga I
AD  - Child Neurology Unit, Pediatrics Department, Hospital Universitario Central de 
      Asturias, Calle de Celestino Villamil, s/n, 33006, Oviedo, Spain.
FAU - Vazquez, Elida
AU  - Vazquez E
AD  - Pediatric Radiology Department, Hospital Universitari Vall d'Hebron, Passeig de 
      la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
FAU - Vicente, Josefina
AU  - Vicente J
AD  - Neuroradiology Department, Hospital Universitario Reina Sofia, Avenida Menendez 
      Pidal, s/n, 14004, Cordoba, Spain.
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140427
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Astrocytoma/diagnosis/diagnostic imaging/therapy
MH  - Brain/*diagnostic imaging/pathology
MH  - Brain Diseases/*diagnostic imaging/*etiology
MH  - Brain Neoplasms/diagnosis/diagnostic imaging/therapy
MH  - Diagnosis, Differential
MH  - Humans
MH  - Neuroimaging/*methods
MH  - Radiography
MH  - Tuberous Sclerosis/*complications/*diagnostic imaging
MH  - Ultrasonography, Prenatal
EDAT- 2014/04/29 06:00
MHDA- 2015/02/05 06:00
CRDT- 2014/04/29 06:00
PHST- 2013/12/06 00:00 [received]
PHST- 2014/03/28 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2015/02/05 06:00 [medline]
AID - 10.1007/s11060-014-1429-y [pii]
AID - 10.1007/s11060-014-1429-y [doi]
PST - ppublish
SO  - J Neurooncol. 2014 Jun;118(2):205-223. doi: 10.1007/s11060-014-1429-y. Epub 2014 
      Apr 27.