PMID- 24772143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140428 LR - 20211021 IS - 1682-024X (Print) IS - 1681-715X (Electronic) IS - 1681-715X (Linking) VI - 30 IP - 2 DP - 2014 Mar TI - The effects of 21 and 23 milimeter aortic valve prosthesis on hemodynamic performance and functional capacity in young adults. PG - 356-60 AB - OBJECTIVE: Early and medium-term improvement of functional capacity and regression of left ventricular hypertrophy was evaluated in the young adult patient group following application of 21 mm or 23 mm bileaflet aortic mechanical valve prosthesis due to aortic stenosis. Methods : Twenty two patients (10 male, 12 female; mean age 27+-8.2 (19-43)) who underwent isolated aortic valve replacement due to rheumatic aortic stenosis, were included in the study. 21 mm and 23 mm bileaflet mechanical prosthesis was used respectively in eight and fourteen patients. The mean body surface area was 1.86 m(2) and 1.68 m(2) respectively in 23 mm and 21 mm prosthesis while 1.73 +/-0.25 m(2) for the whole group. Functional capacity was New York Heart Association (NYHA) class II in 9 patients and class III in thirteen patients. Implantation was performed without enlarging the aortic root in all except four patients. In all patients transvalvular gradients, effective orifice area and the diameter of left ventricle were measured with transthoracic echocardiography during rest and after maximal exercise. Mean follow-up was 34+/-12 months (range 11-57 months). RESULTS: There were no postoperative complications or deaths. All the patients were assessed as NYHA class I with regards to functional capacity (p=0.01). Significant improvements were determined in postoperative mean transvalvular gradient (p=0.005) and left ventricular mass index (p=0.01) when compared with preoperative values. CONCLUSION: Our findings show that replacement with 21 mm and 23 mm mechanical prosthesis provides a significant improvement in regression of symptoms and increase of functional capacity in young adults in early and mid-period without increasing mortality and morbidity. FAU - Yener, Ali Umit AU - Yener AU AD - Ali Umit Yener, Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey. FAU - Ozcan, Sedat AU - Ozcan S AD - Sedat Ozcan, Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey. FAU - Budak, Ali Baran AU - Budak AB AD - Ali Baran Budak, Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey. FAU - Genc, Serhat Bahadir AU - Genc SB AD - Serhat Bahadir Genc, Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey. FAU - Ozkan, Turgut AU - Ozkan T AD - Turgut Ozkan, Department of Cardiovascular Surgery, Canakkale Onsekiz Mart University, Faculty of Medicine, Canakkale, Turkey. FAU - Cicek, Omer Faruk AU - Cicek OF AD - Omer Faruk Cicek, Department of Cardiovascular Surgery, Ankara Yuksek Ihtisas Education and Research Hospital, Ankara-Turkey. LA - eng PT - Journal Article PT - Retracted Publication PL - Pakistan TA - Pak J Med Sci JT - Pakistan journal of medical sciences JID - 100913117 RIN - Pak J Med Sci. 2014 May;30(3):386. PMID: 24966874 PMC - PMC3999010 OTO - NOTNLM OT - Aortic valve OT - aortic valve stenosis OT - echocardiography OT - transvalvular gradient OT - valve surgery EDAT- 2014/04/29 06:00 MHDA- 2014/04/29 06:01 PMCR- 2014/03/01 CRDT- 2014/04/29 06:00 PHST- 2013/10/10 00:00 [received] PHST- 2013/12/13 00:00 [revised] PHST- 2013/12/25 00:00 [accepted] PHST- 2014/04/29 06:00 [entrez] PHST- 2014/04/29 06:00 [pubmed] PHST- 2014/04/29 06:01 [medline] PHST- 2014/03/01 00:00 [pmc-release] AID - pjms-30-356 [pii] PST - ppublish SO - Pak J Med Sci. 2014 Mar;30(2):356-60.