PMID- 24772446
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2014
DP  - 2014
TI  - Proinflammatory and prothrombotic state in subjects with different glucose 
      tolerance status before cardiovascular disease.
PG  - 631902
LID - 10.1155/2014/631902 [doi]
LID - 631902
AB  - BACKGROUND: Inflammation has been associated with insulin resistance, type 2 
      diabetes mellitus (T2DM), and atherothrombosis. AIM: To determine differences in 
      levels of proinflammatory and prothrombotic markers such as high sensitivity 
      C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose 
      tolerance (NGT), prediabetes, and T2DM and to establish their relationship with 
      other cardiovascular risk factors before clinical manifestations of 
      cardiovascular disease. METHODS: We conducted a nonrandomized, cross-sectional 
      assay in a hospital at Mexico City. The levels of hs-CRP and fibrinogen were 
      measured and compared according to glucose tolerance status. RESULTS: We enrolled 
      1047 individuals and they were distributed into NGT n = 473, pre-DM n = 250, and 
      T2DM n = 216. There was a statistical difference between NGT and T2DM groups for 
      fibrinogen (P = 0.01) and hs-CRP (P = 0.05). Fibrinogen and hs-CRP showed a 
      significant positive correlation coefficient (r = 0.53, P<0.0001). In a multiple 
      stepwise regression analysis, the variability in fibrinogen levels was explained 
      by age, HbA1c, and hs-CRP (adjusted R(2) = 0.31, P<0.0001), and for hs-CRP it was 
      explained by BMI and fibrinogen (adjusted R(2) = 0.33, P<0.0001). CONCLUSION: 
      Inflammation and prothrombotic state are present in people with T2DM lacking 
      cardiovascular disease. Fibrinogen and Hs-CRP are positively correlated. 
      Fibrinogen and hs-CRP concentrations are predominantly determined by BMI rather 
      than glucose levels.
FAU - Isordia-Salas, Irma
AU  - Isordia-Salas I
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro" Instituto Mexicano del Seguro 
      Social, Apartado Postal B 32, Coahuila No. 5, 06703 Mexico, DF, Mexico.
FAU - Galvan-Plata, Maria Eugenia
AU  - Galvan-Plata ME
AD  - Servicio de Medicina Interna, UMAE, Hospital de Especialidades, Centro Medico 
      Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 06720 Mexico, DF, 
      Mexico.
FAU - Leanos-Miranda, Alfredo
AU  - Leanos-Miranda A
AD  - Unidad de Investigacion Medica en Medicina Reproductiva, UMAE H.G.O. No. 4, 
      Instituto Mexicano del Seguro Social, 01070 Mexico, DF, Mexico.
FAU - Aguilar-Sosa, Eberth
AU  - Aguilar-Sosa E
AD  - Servicio de Medicina Interna, H.G.Z. A 2 "Francisco del Paso y Troncoso", del 
      Instituto Mexicano del Seguro Social, 08400 Mexico, DF, Mexico.
FAU - Anaya-Gomez, Francisco
AU  - Anaya-Gomez F
AD  - Servicio de Medicina Interna, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sanchez 
      Navarro" Instituto Mexicano del Seguro Social, 03100 Mexico, DF, Mexico.
FAU - Majluf-Cruz, Abraham
AU  - Majluf-Cruz A
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro" Instituto Mexicano del Seguro 
      Social, Apartado Postal B 32, Coahuila No. 5, 06703 Mexico, DF, Mexico.
FAU - Santiago-German, David
AU  - Santiago-German D
AD  - Unidad de Investigacion Medica en Trombosis, Hemostasia y Aterogenesis, H.G.R. 
      No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro" Instituto Mexicano del Seguro 
      Social, Apartado Postal B 32, Coahuila No. 5, 06703 Mexico, DF, Mexico ; Servicio 
      de Urgencias, H.G.R. No. 1 "Dr. Carlos Mac Gregor Sanchez Navarro" Instituto 
      Mexicano del Seguro Social, 03100 Mexico, DF, Mexico.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140317
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/*epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/immunology/*physiopathology
MH  - Early Diagnosis
MH  - Female
MH  - Fibrinogen/analysis
MH  - Glucose Intolerance/blood/complications/immunology/*physiopathology
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Overweight/complications
MH  - Prediabetic State/blood/complications/immunology/*physiopathology
MH  - Risk Factors
MH  - Thrombosis/complications/diagnosis/*etiology
MH  - Vasculitis/complications/diagnosis/*etiology
PMC - PMC3977085
EDAT- 2014/04/29 06:00
MHDA- 2014/10/29 06:00
PMCR- 2014/03/17
CRDT- 2014/04/29 06:00
PHST- 2013/10/02 00:00 [received]
PHST- 2014/01/22 00:00 [accepted]
PHST- 2014/04/29 06:00 [entrez]
PHST- 2014/04/29 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
PHST- 2014/03/17 00:00 [pmc-release]
AID - 10.1155/2014/631902 [doi]
PST - ppublish
SO  - J Diabetes Res. 2014;2014:631902. doi: 10.1155/2014/631902. Epub 2014 Mar 17.