PMID- 2477523
OWN - NLM
STAT- MEDLINE
DCOM- 19891101
LR  - 20200220
IS  - 0894-9255 (Print)
IS  - 0894-9255 (Linking)
VI  - 2
IP  - 5
DP  - 1989
TI  - Antiviral agents with activity against human retroviruses.
PG  - 441-7
AB  - The ability of various known anti-HIV antivirals to inhibit four different 
      strains of human immunodeficiency virus type 1 (HIV-1), a strain of type 2 
      (HIV-2), and a human T-cell lymphotropic virus type I (HTLV-I) was tested. The 
      tested substances included two sulfated polysaccharides (lentinan sulfate and 
      dextran sulfate) and a nonsulfated polysaccharide PSK, E-P-LEM, glycyrrhizin 
      sulfate, and nucleoside analogues (AZT and DHT). The effects of the substances 
      were measured quantitatively with two different assays: (i) inhibition of 
      cell-free viral infection and (ii) inhibition of the fusion reaction induced by 
      cell-to-cell infection. The results showed that cell-free infection of HIV-1 and 
      HIV-2 was almost completely blocked in the presence of all of the substances 
      tested. However, cell-to-cell infection by HIV-1, HIV-2, and HTLV-I was inhibited 
      only by the polysaccharides, E-P-LEM, and glycyrrhizin sulfate but not by the two 
      nucleoside analogues. Moreover, the extent of inhibition of the fusion reaction 
      by the substances varied significantly from strain to strain in HIV-1.
FAU - Tochikura, T S
AU  - Tochikura TS
AD  - Department of Virology and Parasitology, Yamaguchi University School of Medicine, 
      Japan.
FAU - Nakashima, H
AU  - Nakashima H
FAU - Yamamoto, N
AU  - Yamamoto N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr (1988)
JT  - Journal of acquired immune deficiency syndromes
JID - 8812597
RN  - 0 (Antiviral Agents)
RN  - 0 (Dextrans)
RN  - 0 (Dideoxynucleosides)
RN  - 0 (Fungal Proteins)
RN  - 0 (Lentinus edodes mycelia extract E-P-LEM)
RN  - 0 (Polysaccharides)
RN  - 0 (Proteoglycans)
RN  - 114285-68-6 (lentinan sulfate)
RN  - 37339-90-5 (Lentinan)
RN  - 3X48A86C8K (polysaccharide-K)
RN  - 4B9XT59T7S (Zidovudine)
RN  - 6FO62043WK (Glycyrrhizic Acid)
RN  - 9042-14-2 (Dextran Sulfate)
RN  - BO9LE4QFZF (Stavudine)
RN  - P540XA09DR (Glycyrrhetinic Acid)
SB  - IM
MH  - Antiviral Agents/*pharmacology
MH  - Deltaretrovirus/*drug effects/physiology/ultrastructure
MH  - Dextran Sulfate
MH  - Dextrans/pharmacology
MH  - Dideoxynucleosides/pharmacology
MH  - Fungal Proteins/pharmacology
MH  - Glycyrrhetinic Acid/pharmacology
MH  - Glycyrrhizic Acid
MH  - HIV-1/drug effects/physiology/ultrastructure
MH  - HIV-2/drug effects/physiology/ultrastructure
MH  - Human T-lymphotropic virus 1/drug effects/physiology/ultrastructure
MH  - Lentinan/analogs & derivatives/pharmacology
MH  - Polysaccharides/pharmacology
MH  - Proteoglycans/pharmacology
MH  - Stavudine
MH  - Zidovudine/pharmacology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
PST - ppublish
SO  - J Acquir Immune Defic Syndr (1988). 1989;2(5):441-7.