PMID- 24776730
OWN - NLM
STAT- MEDLINE
DCOM- 20150804
LR  - 20161125
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 139
IP  - 12
DP  - 2014 Jun 21
TI  - Label-free selective SERS detection of PCB-77 based on DNA aptamer modified 
      SiO(2)@Au core/shell nanoparticles.
PG  - 3083-7
LID - 10.1039/c4an00197d [doi]
AB  - A label-free approach to selective detection of 3,3',4,4'-tetrachlorobiphenyl 
      (PCB77) using aptamer modified silica-Au/core-shell nanoparticles (denoted as 
      SiO2@Au core/shell NPs) through surface enhanced Raman scattering (SERS) 
      spectroscopy was proposed. The devised system consisted of SiO2@Au core/shell NPs 
      fixed on the amino-silane functionalized glass slides with the PCB77-binding 
      aptamers attached covalently to the gold surfaces through a thiol linker. The 
      aptamers made of single-stranded DNA (ssDNA) oligomers with one end standing on 
      the Au surface changed the conformation upon conjugation with PCB77, which 
      correspondingly caused the spectral response of the ssDNA oligomers. The 
      intensity ratio I(660 cm(-1))/I(736 cm(-1)) decreased with the amount of PCB77 
      added, which thus allowed us to measure trace amounts of PCB77 in a selective and 
      quantitative way. This work therefore demonstrates that the design of 
      aptamer-modified SiO2@Au core/shell NPs can be utilized for label-free SERS 
      detection of persistent organic pollutants (POPs) in the environment.
FAU - Lu, Yilin
AU  - Lu Y
AD  - Key Laboratory of Ion Beam Bio-engineering, Institute of Technical Biology and 
      Agriculture Engineering, Hefei Institutes of Physical Science, Chinese Academy of 
      Sciences, Hefei, 230031, PR China. huangq@ipp.ac.cn.
FAU - Huang, Qing
AU  - Huang Q
FAU - Meng, Guowen
AU  - Meng G
FAU - Wu, Lijun
AU  - Wu L
FAU - Jingjing, Zhang
AU  - Jingjing Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140429
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Aptamers, Nucleotide)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - Y2I6546TMI (3,4,3',4'-tetrachlorobiphenyl)
SB  - IM
MH  - *Aptamers, Nucleotide
MH  - Base Sequence
MH  - *Nanoparticles
MH  - Polychlorinated Biphenyls/*analysis
MH  - Silicon Dioxide/*chemistry
EDAT- 2014/04/30 06:00
MHDA- 2015/08/05 06:00
CRDT- 2014/04/30 06:00
PHST- 2014/04/30 06:00 [entrez]
PHST- 2014/04/30 06:00 [pubmed]
PHST- 2015/08/05 06:00 [medline]
AID - 10.1039/c4an00197d [doi]
PST - ppublish
SO  - Analyst. 2014 Jun 21;139(12):3083-7. doi: 10.1039/c4an00197d. Epub 2014 Apr 29.