PMID- 24777144
OWN - NLM
STAT- MEDLINE
DCOM- 20150312
LR  - 20181202
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 37
IP  - 3
DP  - 2014
TI  - Preventing catheter-related bacteremia with taurolidine-citrate catheter locks: a 
      systematic review and meta-analysis.
PG  - 179-87
LID - 10.1159/000360271 [doi]
AB  - BACKGROUND: Preliminary evidence from some studies suggests that 
      taurolidine-citrate locks decrease catheter-related bacteremia (CRB), which is a 
      major cause of morbidity and mortality in patients using intravascular catheters. 
      No previous study has sought to summarize existing evidence on the use of 
      taurolidine-citrate locks. A systematic review and meta-analysis were undertaken 
      to determine whether taurolidine-citrate was more effective than heparin in the 
      prevention of CRB. METHODS: The major English (PubMed, EBSCO, Web of Science and 
      OVID) and Chinese (CBM, CNKI, VIP and Wanfang Data) healthcare databases were 
      searched for randomized controlled trials comparing the efficacy and safety of 
      taurolidine-citrate lock solution (TCLS) and heparin lock solution in the 
      prevention of CRB. RESULTS: Three studies involving 236 patients with a total of 
      34,984 catheter days were included. The use of TCLS significantly decreased the 
      risk of CRB (relative risk = 0.47, 95% CI: 0.25-0.89) and Gram-negative bacterial 
      infection. There was no significant difference in Gram-positive infections and 
      exit-site infections. CONCLUSIONS: Catheter locking with TCLS reduced the risk of 
      CRB and Gram-negative bacterial infection. Adverse events include thrombotic 
      events.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Liu, Hongbo
AU  - Liu H
AD  - Department of Medicine Clinical Laboratory, The Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - Liu, Hongmei
AU  - Liu H
FAU - Deng, Jing
AU  - Deng J
FAU - Chen, Lihua
AU  - Chen L
FAU - Yuan, Lu
AU  - Yuan L
FAU - Wu, Yong
AU  - Wu Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20140426
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Anticoagulants)
RN  - 0 (Thiadiazines)
RN  - 1EQV5MLY3D (Taurine)
RN  - 2968PHW8QP (Citric Acid)
RN  - 8OBZ1M4V3V (taurolidine)
SB  - IM
MH  - Anti-Infective Agents/*therapeutic use
MH  - Anticoagulants/*therapeutic use
MH  - Bacteremia/etiology/*prevention & control
MH  - Citric Acid/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - PubMed
MH  - Taurine/*analogs & derivatives/therapeutic use
MH  - Thiadiazines/*therapeutic use
MH  - Vascular Access Devices/*adverse effects/microbiology
EDAT- 2014/04/30 06:00
MHDA- 2015/03/13 06:00
CRDT- 2014/04/30 06:00
PHST- 2014/04/30 06:00 [entrez]
PHST- 2014/04/30 06:00 [pubmed]
PHST- 2015/03/13 06:00 [medline]
AID - 000360271 [pii]
AID - 10.1159/000360271 [doi]
PST - ppublish
SO  - Blood Purif. 2014;37(3):179-87. doi: 10.1159/000360271. Epub 2014 Apr 26.