PMID- 24777380
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20140429
IS  - 1869-1889 (Electronic)
IS  - 1674-7305 (Linking)
VI  - 57
IP  - 4
DP  - 2014 Apr
TI  - The role of the N-methyl-D-aspartate receptor in the proliferation of adult 
      hippocampal neural stem and precursor cells.
PG  - 403-11
LID - 10.1007/s11427-014-4637-y [doi]
AB  - New neurons are continuously generated from resident pools of neural stem and 
      precursor cells (NSPCs) in the adult brain. There are multiple pathways through 
      which adult neurogenesis is regulated, and here we review the role of the 
      N-methyl-D-aspartate receptor (NMDAR) in regulating the proliferation of NSPCs in 
      the adult hippocampus. Hippocampal-dependent learning tasks, enriched 
      environments, running, and activity-dependent synaptic plasticity, all potently 
      up-regulate hippocampal NSPC proliferation. We first consider the requirement of 
      the NMDAR in activity-dependent synaptic plasticity, and the role the induction 
      of synaptic plasticity has in regulating NSPCs and newborn neurons. We address 
      how specific NMDAR agonists and antagonists modulate proliferation, both in vivo 
      and in vitro, and then review the evidence supporting the hypothesis that NMDARs 
      are present on NSPCs. We believe it is important to understand the mechanisms 
      underlying the activation of adult neurogenesis, given the potential that 
      endogenous stem cell populations have for repopulating the hippocampus with 
      functional new neurons. In conditions such as age-related memory decline, 
      neurodegeneration and psychiatric disease, mature neurons are lost or become 
      defective; as such, stimulating adult neurogenesis may provide a therapeutic 
      strategy to overcome these conditions.
FAU - Taylor, Chanel J
AU  - Taylor CJ
AD  - Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 
      4072, Australia.
FAU - He, RongQiao
AU  - He R
FAU - Bartlett, Perry F
AU  - Bartlett PF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140314
PL  - China
TA  - Sci China Life Sci
JT  - Science China. Life sciences
JID - 101529880
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Hippocampus/*cytology
MH  - Humans
MH  - Long-Term Potentiation
MH  - Mice
MH  - Neural Stem Cells/*cytology
MH  - Neurogenesis
MH  - Neuronal Plasticity
MH  - Neurons/metabolism/physiology
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/metabolism/*physiology
MH  - Synapses/metabolism
EDAT- 2014/04/30 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/04/30 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/04/30 06:00 [entrez]
PHST- 2014/04/30 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1007/s11427-014-4637-y [doi]
PST - ppublish
SO  - Sci China Life Sci. 2014 Apr;57(4):403-11. doi: 10.1007/s11427-014-4637-y. Epub 
      2014 Mar 14.