PMID- 24777423
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181202
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Linking)
VI  - 21
IP  - 3
DP  - 2015 Jun
TI  - Grafted bone marrow stromal cells: a contributor to glial repair after spinal 
      cord injury.
PG  - 277-89
LID - 10.1177/1073858414532171 [doi]
AB  - In the CNS, astrocytes, oligodendrocytes and microglias are involved in not only 
      development but also pathology such as spinal cord injury (SCI). Glial cells play 
      dual roles (negative vs. positive effects) in these processes. After SCI, 
      detrimental effects usually dominate and significantly retard functional 
      recovery, and curbing these effects is critical for promoting neurological 
      improvement. Bone marrow stromal cells (BMSCs) represent a new therapeutic 
      approach for SCI by enabling improved sensory and motor functions in animal 
      models. Although transdifferentiation to spinal neurons was poor, because of 
      their pleiotropic nature, the protective effects of BMSCs are broad and are 
      primarily mediated through modulation of transdifferentiation into host spinal 
      glial components. Transplantation of BMSCs can positively alter the spinal 
      microenvironment and enhance recovery. The objective of this review is to discuss 
      these and other related mechanisms. Since BMSCs transplantation has been applied 
      in other clinical fields, we hope to provide useful clues for the clinical 
      application of BMSCs to treat the SCI in the near future.
CI  - (c) The Author(s) 2014.
FAU - Zhang, Li-Xin
AU  - Zhang LX
AD  - Department of Rehabilitation, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, China uzhanglx@aliyun.com.
FAU - Yin, Yan-Mei
AU  - Yin YM
AD  - Department of Rehabilitation, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, China.
FAU - Zhang, Zhi-Qiang
AU  - Zhang ZQ
AD  - Department of Rehabilitation, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, China.
FAU - Deng, Ling-Xiao
AU  - Deng LX
AD  - Department of Anatomy and Cell Biology, Indiana University School of Medicine, 
      Indianapolis, IN, USA Spinal Cord and Brain Injury Research Group, Stark 
      Neurosciences Research Institute, and Department of Neurological Surgery, Goodman 
      Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, 
      IN, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140428
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*physiology
MH  - Nerve Regeneration
MH  - Neuroglia/*physiology
MH  - Recovery of Function
MH  - Spinal Cord Injuries/*physiopathology/*therapy
OTO - NOTNLM
OT  - astrocyte
OT  - bone marrow stromal cells (BMSCs)
OT  - glial scar
OT  - inflammation
OT  - microglia
OT  - myelination
OT  - oligodendrocyte
OT  - spinal cord injury (SCI)
EDAT- 2014/04/30 06:00
MHDA- 2016/02/03 06:00
CRDT- 2014/04/30 06:00
PHST- 2014/04/30 06:00 [entrez]
PHST- 2014/04/30 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - 1073858414532171 [pii]
AID - 10.1177/1073858414532171 [doi]
PST - ppublish
SO  - Neuroscientist. 2015 Jun;21(3):277-89. doi: 10.1177/1073858414532171. Epub 2014 
      Apr 28.