PMID- 24779464 OWN - NLM STAT- MEDLINE DCOM- 20150302 LR - 20140704 IS - 1943-3700 (Electronic) IS - 0090-3558 (Linking) VI - 50 IP - 3 DP - 2014 Jul TI - Antibodies to rabies virus in terrestrial wild mammals in native rainforest on the north coast of Sao Paulo State, Brazil. PG - 469-77 LID - 10.7589/2013-04-099 [doi] AB - Rabies causes thousands of human and animal deaths worldwide each year. The emergent importance of rabies in wild animals demonstrates the necessity of epidemiologic studies of infection in these species toward the development of better strategies for prevention and control of rabies. We analyzed the circulation of rabies virus among wildlife species from a native rainforest in Sao Paulo State, Brazil. We used the rapid fluorescent focus inhibition test (RFFIT) to test for rabies virus-neutralizing antibodies in 139 captured terrestrial mammals and the fluorescent antibody test (FAT), mouse inoculation test (MIT), and reverse-transcriptase (RT)-PCR to test for virus in samples from the central nervous system of 53 animals found dead. The percentage of samples positive by RFFIT was 10.8%. All samples tested by FAT, MIT, and RT-PCR were negative. Research should be continued to obtain a better understanding of the role of wildlife in the circulation and transmission of rabies virus. FAU - Araujo, Danielle B AU - Araujo DB AD - 1 Center for Research on Rabies, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1374, Room 225, Butantan, CEP 05508-900, Sao Paulo, SP, Brazil. FAU - Martorelli, Luzia A AU - Martorelli LA FAU - Kataoka, Ana Paula G A AU - Kataoka AP FAU - Campos, Angelica C A AU - Campos AC FAU - Rodrigues, Camila S AU - Rodrigues CS FAU - Sanfilippo, Luiz F AU - Sanfilippo LF FAU - Cunha, Elenice S AU - Cunha ES FAU - Durigon, Edison L AU - Durigon EL FAU - Favoretto, Silvana R AU - Favoretto SR LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140429 PL - United States TA - J Wildl Dis JT - Journal of wildlife diseases JID - 0244160 RN - 0 (Antibodies, Viral) SB - IM MH - Animals MH - *Animals, Wild MH - Antibodies, Viral/*blood/immunology MH - Biological Assay MH - Brazil/epidemiology MH - Ecosystem MH - Fluorescent Antibody Technique MH - *Mammals MH - Rabies/epidemiology/immunology/*veterinary MH - Rabies virus/*immunology OTO - NOTNLM OT - Brazil OT - diagnosis OT - epidemiology OT - rabies OT - serology OT - wild mammals EDAT- 2014/05/02 06:00 MHDA- 2015/03/03 06:00 CRDT- 2014/05/01 06:00 PHST- 2014/05/01 06:00 [entrez] PHST- 2014/05/02 06:00 [pubmed] PHST- 2015/03/03 06:00 [medline] AID - 10.7589/2013-04-099 [doi] PST - ppublish SO - J Wildl Dis. 2014 Jul;50(3):469-77. doi: 10.7589/2013-04-099. Epub 2014 Apr 29.