PMID- 24779476
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20220317
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 14
DP  - 2014 Apr 29
TI  - Predictors of positive response to cardiac resynchronization therapy.
PG  - 55
LID - 10.1186/1471-2261-14-55 [doi]
AB  - BACKGROUND: Approximately 30% of patients treated with cardiac resynchronization 
      therapy (CRT) do not achieve favourable response. The purpose of the present 
      study was to identify echocardiographic and clinical predictors of a positive 
      response to CRT. METHODS: The study included 82 consecutive heart failure (HF) 
      patients in New York Heart Association (NYHA) functional class III or IV with 
      left bundle branch block (LBBB), QRS duration >/= 120 ms and left ventricular 
      ejection fraction (LVEF) </= 35%. Statistical analysis was performed using IBM SPSS 
      statistical software (SPSS v.21.0 for Mac OS X). A p value < 0.05 was considered 
      statistically significant. RESULTS: Echocardiographic response was established in 
      81.6% and clinical response was achieved in 82.9% of patients. Significant 
      univariate predictors of favourable echocardiographic response after 12 months 
      were smaller left ventricular end-diastolic diameter (LVEDD) (odds ratio [OR] 
      0.89; 95% confidence interval [CI] 0.82 - 0.97, p = 0.01), and smaller left 
      ventricular end-systolic diameter (LVESD) (OR 0.91; 95% CI 0.85 - 0.98, 
      p = 0.01). Lower uric acid concentration was associated with better 
      echocardiographic response (OR 0.99; 95% CI 0.99 - 1.0, p = 0.01). Non-ischemic 
      HF etiology (OR 4.89; 95% CI 1.39 - 17.15, p = 0.01) independently predicted 
      positive clinical response. Multiple stepwise regression analysis demonstrated 
      that LVEDD lower than 75 mm (OR 5.60; 95% confidence interval [CI] 1.36 - 18.61, 
      p = 0.01) was the strongest independent predictor of favourable echocardiographic 
      response. CONCLUSIONS: Smaller left ventricular end-diastolic and end-systolic 
      diameters and lower serum uric acid concentration were associated with better 
      response to CRT. Left ventricular end-diastolic diameter and non-ischemic heart 
      failure etiology were the strongest independent predictors of positive response 
      to CRT.
FAU - Rinkuniene, Diana
AU  - Rinkuniene D
AD  - Lithuanian University of Health Sciences, Kaunas, Lithuania. 
      diana.rinkuniene@gmail.com.
FAU - Bucyte, Silvija
AU  - Bucyte S
FAU - Ceseviciute, Kristina
AU  - Ceseviciute K
FAU - Abramavicius, Silvijus
AU  - Abramavicius S
FAU - Baronaite-Dudoniene, Kristina
AU  - Baronaite-Dudoniene K
FAU - Laukaitiene, Jolanta
AU  - Laukaitiene J
FAU - Kazakevicius, Tomas
AU  - Kazakevicius T
FAU - Zabiela, Vytautas
AU  - Zabiela V
FAU - Sileikis, Vytautas
AU  - Sileikis V
FAU - Puodziukynas, Aras
AU  - Puodziukynas A
FAU - Jurkevicius, Renaldas
AU  - Jurkevicius R
LA  - eng
PT  - Journal Article
DEP - 20140429
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - *Cardiac Resynchronization Therapy
MH  - Chi-Square Distribution
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Conduction System/physiopathology
MH  - Heart Failure/blood/diagnostic imaging/physiopathology/*therapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Uric Acid/blood
MH  - Ventricular Function, Left
PMC - PMC4016658
EDAT- 2014/05/02 06:00
MHDA- 2015/01/21 06:00
PMCR- 2014/04/29
CRDT- 2014/05/01 06:00
PHST- 2014/03/02 00:00 [received]
PHST- 2014/04/23 00:00 [accepted]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2014/05/02 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
PHST- 2014/04/29 00:00 [pmc-release]
AID - 1471-2261-14-55 [pii]
AID - 10.1186/1471-2261-14-55 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2014 Apr 29;14:55. doi: 10.1186/1471-2261-14-55.